| Objective: Intracerebral hemorrhage is a very common acute cerebral vascular accident, which incidence rate is 60~80 persons/ 100,000 population/year accounting for 20~30% in acute cerebrovascular disease. The cause of Intracerebral hemorrhage often ralated to hypertension or small artery atherosclerosis . The investigation showed that intracerebral hemorrhage has a higher mortality and morbidity ,which mortality rate in 30d is 50%and at least 30% patients will leave behind the nerve function barrier or the bodily organ's disability lifelong,is higher than any other acute cerebrovascular disease and until now still lackes the effective treatment.Besides investigating whose cause , in addition to the oppression of bleeding location for the brain tissue ,the more important is that the formation of brain edema after the cerebral hemorrhage and the damage of harmful substances to brain cells. So investigates mechanism of the nerve damage after cerebral hemorrhage and adopts the target-oriented treatments will be have a remarkable significance regarding cerebral hemorrhage patients acute stage's treatment and improvement the prognosis. The animal cerebral hemorrhage model demonstrated that cerebral hemorrhage cerebellum iron begin to rase on the 1st day, 3rd day reaches the peak, which is match with the peak 3-4 day of brain edema after the cerebral hemorrhage. Iron chelator deferoxamine can obviously decrease cerebral edema. It can be seen that cerebral hemorrhage queen cruorin degradation outcome determines ,be playing important role in the field of acute scheduled time hydrocephalus formation, but reason iron is upright delayed nature hydrocephalus mechanism leading not by very clear expounding. Serum ferritin as indicator of iron overload in vivo, can reflect the changes of brain edema.There are very little relevant research about serum ferritin level and perihematoma edema volume in patients with spontaneous intracerebral hemorrhage. We undertook this exploratory study to investigate the association of serum ferritin, as an indicator of body iron load, with perihematoma edema after ICH. The purpose of this exploratory study is to investigate the association of serum ferritin level with perihematoma edema after acute intracerebral hemorrhage. Research Subjects and Methods: We retrospectively reviewed our prospectively collected stroke from may 2008 to March 2009. All patients confirmed by head CT in order to comply with standards selected 27 cases of patients with cerebral hemorrhage, 16 cases were male, accounting for 59%, female 11 cases, accounting for 41%, age 48 to 82 years old, on average (56.1±12.2years). Among them, 13 patients (48%) for the putaminal hemorrhage, 8 cases (30%) for the thalamic hemorrhage, 6 cases (22%) for lobar hemorrhage, and hemorrhage were unilateral. All patients had a baseline computerized axial tomography (CT) scan and serum ferritin level checked on admission. database for consecutive patients with ICH admitted to our service. All patients were measured serum ferritin level within 24 hours given a baseline computerized axial tomography (CT) scan within 12 hours and review head CT 3 or 4 days later. A single evaluator (M.M.) experienced in the interpretation of CT and blinded to patients'clinical and biochemical data analyzed all CT scans to conduct volumetric measurements of ICH and edema lesion volumes. All images were processed off-line with the use of an imaging processing software running on an AW4.2 GE Advantage workstation. The ICH and edema volumes were calculated using a semiautomated process. To control for hematoma volume, we subtracted the hematoma volume from that of the absolute edema, and divided the product by the hematoma volume, to express perihematoma edema volume as a ratio of the associated hematoma volume (relative edema volume). The measured data was analysised by SPSS 16.0 statistical software package. Result: 1. Compared with normal contro(l119.83±47.17μg/L),ICH patients'serum ferritin level (306.92±49.98μg/L)raised within 24 hours ,which had significant deviation (P<0.05). 2 There was no linear correlation between serum ferritin within 24 hours and relative perihematoma edema volume within 12 hours (r=0.303; P=0.124). However ,there was a positive correlation between serum ferritin within 24 hours and the relative perihematoma edema volume on 3 to 4 days(r=0.733; P=0.000). Conlution:this study provides evidence that serum ferritin levels within 24 hours correlate with the relative perihematoma edema volume after ICH.Furthermor, serum ferritin level within 24 hours might be descripte peak brain edema volume ,which can provide a clue for evaluation and treatment of ICH. |
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