| Objective: Previous studies have indicated that the Tpeak-Tend inter- val (Tpe) could represent the transmural dispersion of ventricular repolari- zation, and might serve as a non-invasive prognostic index of the malignant ventricular tachyarrhythmia, which was a major cause of sudden death in hypertrophic (HCM) and dilated cardiomyopathy (DCM). This study aimed to evaluate the characteristics of the Tpe in patients with and without HCM and DCM.Method: Forty one inpatients were enrolled in this study, which inclu- des 21 patients with primary HCM (male 10, aged 33~65, 47.95±10.14 ys; Group HCM), 20 with primary DCM (male 14, aged 27~58, 47.15±8.42 ys; Group DCM), and 19 without structural heart disease (male 14, aged 21~51, 38.74±6.51 ys; Group Control). The Tpe and the dispersion of QT interval (QTd) from the 12-lead surface ECG were acquired and measured mannua- lly in the 60 patients of the three groups, and consequently the corrected numerals of the average of Tpe, the maximal Tpe, the Tpe of lead V1, V5, II were calculated, which was named as Tpe-AVEC,Tpe-MAXC,Tpe-V1C,Tpe-V5C and Tpe-IIC,respectively.The corrected numerals and QTd were then comp- ared between the Group HCM and Control, as well as the Group DCM and Control.Results: 1. The comparison between the Group HCM and Control: In Group HCM, the Tpe-AVEC,Tpe-MAXC,Tpe-IIC and QTd were all significantly greater than those of Group Control, which were 91.3±13.1vs.82.7±10.0(P< 0.05),154.7±31.5vs.119.2±11.6(P<0.05),93.6±34.1vs.72.5±13.5(P<0.05)and 59.1±21.3vs.39.7±17.0(P<0.05),respectively.However,no significant differ- ences were found in Tpe-V1C(94.6±26.2vs.87.2±21.2,P>0.05) and Tpe-V5C (89.0±20.9vs.86.9±12.7,P>0.05) in the two groups. 2. The comparison be- tween the Group DCM and Control: In Group DCM, the Tpe-AVEC, Tpe-MAXC, Tpe-IIC and QTd were all significantly greater than those of Group Control, which were 95.7±14.3vs.82.7±10.0 (P<0.05),148.5±28.8vs.119.2±11.6(P< 0.05),90.8±19.7vs.72.5±13.5(P<0.05),53.3±19.8vs.39.7±17.0(P<0.05), res- pectively. However, no significant differences were found in Tpe-V1C (96.6±19.1vs.87.2±21.2,P>0.05) and Tpe-V5C (99.5±25.1 vs. 86.9±12.7,P>0.05) in the two groups.Conclusion: In this study, the Tpe were significantly prolonged in pa- tients with HCM and DCM, which suggested that the Tpe might serve as a non-invasive index for malignant ventricular tachyarrhythmia in such pa- tients. The Tpe-AVEC, Tpe-MAXC and Tpe-IIC were significantly increased in Groups of HCM and DCM, whereas no differences were found in Tpe-V1C and Tpe-V5C, which indicated that Tpe might represent the global, but not the transmuarl dispersion of ventricular repolarization. Furthermore, the measurement methods of Tpe should be cautioned,and the Tpe-AVE, Tpe-MAX and Tpe-II were recommended to be used for evaluation of the ventricular repolarization dispersion as the prognostic index in patients with HCM and DCM. |
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