The Study Of Executive Dysfunction And Related Factors Among Type Ⅱ Diabetes Patients

Objective: To investigate the characteristics of executive dysfunction and the associated factors in middle-aged patients with type II diabetes (T2DM).Methods: A case-control study was conducted. With the Mini-Mental State Examination(MMSE),Wisconsin card sorting test (WCST),Stroop color-word test (SCWT) and the Digit Span Test (DST) to assess the cognitive function of 71 middle-aged patients and 33 control subjects.Results: (1) The MMSE scores of case and control groups are 28.39±1.21 and 28.79±1.16, which had no statistical difference. The WCST and SCWT scores of diabetic patients are significantly lower than that of normal controls. (2) The errors of card C and SIE in 40~49-years old groups is significantly higher than normal controls;The errors of card C,the reaction time of card C and SIE in 50~60 years groups is significantly higher than that of normal control people. (3) The errors of card C,reaction time of card C and SIE in male groups is not significantly higher than that of normal control people;The errors of card C and SIE in female groups is significantly higher than that of normal control people. The reaction time of card C and SIE is not significantly higher than that of normal control people. (4) The scores of SDS shown that in the case group are higher than those in the control group. There is a significantly difference rank distributing of depression between two groups. (5) The WCST is positively associated with the backwards recite in diabetes patients. (6) The WCST and SCWT scores of diabetic patients are positively associated with their illness courses, glycemia levels and combined micro-neopathy significantly. Which it has a negative correlation with their education.Conclusion: (1) Type II diabetes is associated with executive dysfunction in a number of cognitive domains including inhibition of proponents responses,concept formation and fluency. (2) The executive dysfunction of patients has a causal relationship with glycemia levels and complications, such as combined diabetic micro- neopathy. The executive dysfunction has a positive relation with their illness courses. and has a negative correlation with their education. (3) There is a depressed mood in middle-aged patients.