Contrast-enhanced FLAIR Sequence In The Diognosis Of Leptomeningeal Lesions

Objective Use FLAIR (fluid-attenuated inversion recovery), contrast-enhanced T1WI and contrast-enhanced FLAIR sequences in detection of leptomeningeal lesions and combine clinical presentation and laboratory test to evaluate contrast-enhanced FLAIR sequences in detection of leptomeningeal lesions.Method (1)141 patients with a variety of leptomeningeal lesions were analyzed. The MRI protocol included contrast-enhanced T1WI and contrast-enhanced FLAIR sequences. Comparisons between them were made to determine which best depicted lesion; 40 patients with a variety of leptomeningeal lesions were analyzed. The MRI protocol included FLAIR,contrast-enhanced T1WI and contrast-enhanced FLAIR sequences. Comparisons among them were made to determine which best depicted lesion. (2)66 patients with a variety of infection leptomeningeal lesions were analyzed. MRI protocol included contrast-enhanced T1WI and contrast-enhanced FLAIR sequences. Comparisons between them which is best correlation with the clinical results.Results (1)Leptomeningeal lesions showed either diffusely or locally abnormal hyper-intensity along sulci or cistern on three sequences.(2)â‘ Comparisons of contrast-enhanced T1WI and contrast-enhanced FLAIR sequences in detecting 141 abnormalities of sulci showed:contrast-enhanced FLAIR revealed all abnormalities (141/141) and 118 were superior contrast enhancement; contrast-enhanced T1WI revealed 95 abnormalities (95/141) and 61 were superior contrast enhancement.â‘¡Comparisons of contrast-enhanced TIWI and contrast-enhanced FLAIR sequences in detecting 74 patients of viral meningitis or meningoencephalitis showed:contrast-enhanced FLAIR revealed all abnormalities (74/74) and 62 were superior contrast enhancement; contrast-enhanced TIWI revealed 48 abnormalities (48/74) and 25 were superior contrast enhancement.â‘¢Comparisons of contrast-enhanced T1WI and contrast-enhanced FLAIR sequences in detecting 28 patients of tuberculous meningitis showed:contrast-enhanced FLAIR revealed all abnormalities (28/28) and 26 were superior contrast enhancement; contrast-enhanced TIWI revealed 48 abnormalities (21/28) and 14 were superior contrast enhancement.â‘£Comparisons of contrast-enhanced T1WI and contrast-enhanced FLAIR sequences in detecting 15 patients of purulent meningitis showed:contrast-enhanced FLAIR revealed all abnormalities (15/15) and 12 were superior contrast enhancement; contrast-enhanced T1WI revealed all abnormalities (15/15) and 10 were superior contrast enhancement.(3)â‘ Comparisons of un-enhanced FLAIR,contrast-enhanced TIWI and contrast-enhanced FLAIR sequences in detecting 40 abnormalities of sulci showed: contrast-enhanced FLAIR revealed all abnormalities (40/40) and 35 were superior contrast enhancement; contrast-enhanced T1WI revealed 26 abnormalities (26/40) and 14 were superior contrast enhancement. un-enhanced FLAIR revealed 19 abnormalities (19/40) and 8 were superior delineated.â‘¡Comparisons of un-enhanced FLAIR,contrast-enhanced T1WI and contrast-enhanced FLAIR sequences in detecting 74 patients of viral meningitis or meningoencephalitis showed: contrast-enhanced FLAIR revealed all abnormalities (16/16) and 14 were superior contrast enhancement; contrast-enhanced TIWI revealed 9 abnormalities (9/16) and 4 were superior contrast enhancement. un-enhanced FLAIR revealed 8 abnormalities (8/16) and 3 were superior delineated.â‘¢Comparisons of un-enhanced FLAIR,contrast-enhanced TIWI and contrast-enhanced FLAIR sequences in detecting 10 patients of tuberculous meningitis showed:contrast-enhanced FLAIR revealed all abnormalities (10/10) and 9 were superior contrast enhancement; contrast-enhanced T1WI revealed 9 abnormalities (9/10) and 5 were superior contrast enhancement. un-enhanced FLAIR revealed 3 abnormalities (3/10) and 2 were superior delineated.(4)â‘ Comparisons of contrast-enhanced T1WI and contrast-enhanced FLAIR sequences in detecting 42 patients of viral meningitis or meningoencephalitis of correlation with clinical results showed:Enhanced FLAIR and the microscopic level of white blood cells per cubic millimeter were correlated,and enhanced FLAIR and the cerebrospinal fluid examination results were correlated,,and enhanced FLAIR is no correlation with other clinical results. Enhanced T1WI is no correlation with every clinical results.â‘¡Comparisons of contrast-enhanced T1WI and contrast-enhanced FLAIR sequences in detecting 15 patients tuberculous meningitis of correlation with clinical results showed:Enhanced FLAIR and enhanced T1WI are no correlation with every clinical results.â‘¢Comparisons of contrast-enhanced T1WI and contrast-enhanced FLAIR sequences in detecting 9 patients purulent meningitis of correlation with clinical results showed:Enhanced FLAIR and enhanced T1WI are no correlation with every clinical results.Conclusion Contrast-enhanced FLAIR images were superior to un-enhanced FLAIR images and contrast-enhanced T1WI in detection of leptomeningeal lesions. So Contrast-enhanced FLAIR images are helpful and should be considered when findings on un-enhanced FLAIR images and/or contrast-enhanced T1WI are inconclusive.