| [Aims] To investigate the colonic dynamics, anorectal motility, anorectal sensation and psychology in patients who was diagnosed with functional constipation (FC) and explore the possible pathophysiology.[Materials and Methods] Eight-two patients with FC and 38 healthy controls who was diagnosed by Rome III in Department of Gastroenterology, China-Japan Friendship Hospital, between July 2007 and October 2008 were included in our study. Total and segmental colonic transit times and transit index were assessed using radiopaque markers method, anorectal manometry and rectal sensory function was tested by UPS2020 testing system, and psychological testing was performed by the Zung Self-Rateing Anxiety Scale and Zung Self-Rateing Depression Scale.[Results] The colonic transit time in patients with FC was significantly prolonged than that controls. Lower anorectal sphincteric resting pressure (P<0.05), lower anorectal sphincteric maximum squeezing pressure (P<0.05), and longer length of anal high pressure zone (P<0.05) were observed in patients with FC. Patients displayed larger minimum relaxation volume, larger first sensitive volume, larger rectal maximum tolerable volume thresholds compared with healthy controls. Compared with the health controls, patients with FC have higher scores not only in anxiety but also in depreesion.(P<0.05). After two months' treatment, patients with FC show higher anorectal sphincteric maximum squeezing pressure, less first sensitive volume, less rectal maximum tolerable volume thresholds compared with that before treatment. Moreover, the scores of SAS and SDS apparently decline after treatment.[Conclusion] The abnormalities of gut motility, visceral perception and psychological disordrers may be involved in the pathogenesis of constipation. Abnormal psychological statement was often found in patients with FC. The symptoms, parameters of anoretal motility and perception were improved through treatment in patients with FC.
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