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Effect Of Thalidomide On Cytokines And Cellular Immune Function In Cases Of Pandemic H1N1 2009 Influenza Virus Infection

Posted on:2011-10-09Degree:MasterType:Thesis
Country:ChinaCandidate:Y D WangFull Text:PDF
GTID:2144360302994219Subject:Critical Care Medicine
Abstract/Summary:PDF Full Text Request
Aim:This study aimed to investigate the tendency of cytokines and T lymphocyte subsets in cases of pandemic H1N1 2009 and evaluate the effect of thalidomide on cytokines and T lymphocyte subsets of influenza A/H1N1 patients.Method:During 12,2009 and 2,2010, we observed 20 patients infected influenza A (H1N1) virus who were admited in Intensive Care Unit of the First Affiliated Hospital of Kunming Medical College. Oxygenation index of 200 as the boundary point before thalidomide was given, they were divided into the oxygenation index> 200 group and oxygenation index< 200 group, and the change of cytokines and T lymphocyte subsets were monitored.Result:1.Interleukin-2 (IL-2):Compared with oxygenation index>200, IL-2 significantly increased on the day of admission and the first day of treatment in oxygenation index<200, and P<0.05.2. Interleukin-4 (IL-4):Compared with oxygenation index>200, IL-4 markedly increased on the third day of therapy in oxygenation index<200, and P<0.05.3. Interleukin-6 (IL-6):The mean of IL-6 significantly decreased from 27.26±27.88 pg/ml to 1.15±0.51 pg/ml. Compared with oxygenation index>200, IL-6 obviously on the day of admission and the first day of therapy in oxygenation index<200, and P<0.05.4. Interleukin-10 (IL-10):Compared with oxygenation index>200, IL-10 obviously increased on the day of admission and the third of therapy in oxygenation index<200 group, and P<0.05.5. Tumor necrosis factor-a (TNF-a):The mean of TNF-a significantly decreased from 37.56±48.48 pg/ml to 6.25±9.29 pg/ml. Compared with oxygenation index>200, TNF-a significantly increased in oxygenation index<200, and P<0.05.6. Total T lymphocyte:The mean of total T lymphocyte obviously increased with therapy and total T cell significantly decreased on the day of admission in oxygenation index<200 group compared with oxygenation index>200, and P<0.05.7. T-helper lymphocyte (Th):T-helper lymphocyte amount increased with therapy. There was significantly higher on the third and the fifth day than the day of admission, and P<0.05.8. T-supressor lymphocyte (Ts):,T-supressor lymphocyte amount increased with therapy. There was significantly higher on the first, the third, the fifth day than the day of admission, and P<0.05.9. NK lymphocyte (NK):Compared with oxygenation index >200, NK amount significantly decreased on the first, the third and the fifth day of therapy, and P<0.05.10. Th/Ts:Th/Ts ratio was significantly higher on the fifth day than on the third day of therapy, P<0.05.Conclusions:1.IL-2, IL-6, IL-10 and TNF-a were higher in severe cases of pandemic H1N12009 influenza virus infection (oxygenation index<200) than oxygenation index>200 group.2. Total T cells amount and T-helper lymphocyte amount decreased in cases of H1N1 2009 influenza virus infection, and cellular immune function of patients was damaged; Total T cells amount, T-helper lymphocyte amount, T-supressor lymphocyte amount, NK lymphocyte amount and Th/Ts ratio decreased in severe cases than oxygenation index>200 group.3. After thalidomide was given, proinflammatory factors (IL-2, IL-6, TNF-a) decreased, but the amount of total T cells, Th and Ts increased.
Keywords/Search Tags:Influenza A/H1N1, Cytokine, T lymphocyte subsets, Immune function
PDF Full Text Request
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