Expression Of Galectin-3 And Cytokeratin-19 In Different Area Of Hashimoto Thyroiditis With Thyroid Papillary Microcarcinoma

[Objective] To detect the expression of galectin-3 and cytokeratin-19 in different area of Hashimoto thyroiditis with thyroid papillary microcarcinoma[Methods] Immunohistochemical methods used to examine expression of galectin-3 and cytokeratin-19 in the area of tumor,0.5cm near the tumor and other lobec thyroid in 25 Hashimoto thyroiditis patients,25 thyroid papillary microcarcinoma patents,25 Hashimoto thyroiditis with thyroid papillary microcarcinoma patients[Results] the research results indicated,the lower expression of galectin-3 and cytokeratin-19 in normal thyroid,s tissue;The positive rate of Galectin-3 and CK-19 in the area of 0.5cm near the tumor of the contrast group A were 52%(13/25)and 44 %(11/25) which were superior than what in the contrast group B(P<0.05);but indicated no difference between the contrast group A(P>0.05); The positive rate of Galectin-3 and CK-19 in the area of 0.5cm near the tumor of the contrast group A were Weak positive 69.23%(9/13),72.73%(8/11).positive 23.08%(3/13),18.18 %(2/11)and Strong positive 7.69%(1/13),9.09%(1/11) matched along with Weak positive 36.84%(7/19),29.41%(5/17); positive 36.84%(7/19),47.06% (8/17)and Strong positive 26.32%(5/19),23.53%(4/17)in the test group; the positive and strong positive groups showed evidently difference(P<0.05).[Conclusion]1.Galetin-3 protein assay combined with CK-19 are helpful to differentiate the benign thyroid tumor and malignant one.2.The expression of Galectin-3 and Cytokeratin-19 protein in Hashimoto thyroiditis is clear higher than what in normal thyroid tissue,it is means that prognosis evalution in Hashimoto thyroiditis canceration. 3.Galectin-3 protein assay combined with CK-19 are useful in early diagnosis, the pathogenesis and prognosis evaluation thyroid cancer. When they are strong positive mean it is cancer.4.In Hashimoto thyroiditis with thyroid papillary microcarcinoma,it need a operation therapy, and need a larger one,maybe one total and the other one subtotal or both total.