| Objective To compare the postoperative cognition function and serum S100βprotein levels in geriatric patients following off-pump coronary artery bypass grafting with different anesthesia.Methods 30 ASA physical statusⅡ-Ⅲaged patients undergoing off-pump coronary artery bypass grafting were randomly assigned to isoflurane inhalation group (group A,15) and propofol intravenous group (group B,15). The mini-mental state examination (MMSE) was used to assess the cognitive function before and 4 days after the operation. The radial arterial blood was taken at three time points to measure the blood concentration of S100βprotein.Results There were 5 patients suffered postoperative cognitive dysfunction in group A (33%),and 3 cases in group B(20%). The MMSE score at 4 days in group A and B obviously reduces (P<0.01, P<0.05),but that in group A was lower (P<0.05). The serum concentration of S100βafter the operation of the two groups was different from that before the operation. The serum concentration of S100βwas higher in group A at the end of surgery and 1 day after operation than that in group B (P<0.05)Conclusion With intravenous anesthesia postoperative cognitive dysfunction formation rate and serum S100βprotein concentration change are lower than that of inhalation anesthesia for aged patients during off-pump coronary artery bypass grafting. Propofol intravenous anesthesia has better protection effects than isoflurane inhalation anesthesia during off-pump coronary artery bypass grafting.
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