Effect Of The Low-osmolality Nomomc Contrast Media On Renal Function In Patients Undergoing Cerebrovascular Intervention

Objective:To analyse the effect of the low osmolar nonionic contrast medium on renal function in patients undergoing cerebrovascular intervention.To study the clinical attention to contrast-induced nephropathy(CIN) and incidence and risk factors of contrast-induced nephropathy (CIN).Methods:Two hundred and ninety four patients undergoing cerebrovascular intervention from January 2009 to December 2009 were enrolled in this study. All patients received low-osmolality nonionic contrast agent. Scr and Ccr were collected at any time three days before the angiography and at 48h post procedure. To study the clinical attention to contrast-induced nephropathy(CIN) and incidence and risk factors of contrast-induced nephropathy (CIN). Multivariate predictors of contrast-induced nephropathy were determined using logistic regression.Results:1.Among the 294 patients,162 were males and 132 females.85 patients (28.9%) reexamination Cr 48h after cerebrovascular intervention.2. analyse this 85 patients(1) Among the 85 patients,49 were males and 36 females,The average age Was (53.1±10.6)years. five patients(5.8%)experienced CIN and the incidence of CIN was 5.8%.(2) Among the 85 patients,74 patients had normal renal function, and 11 patients had renal insufficiency.There was no significant change of Scr and Ccr after angiography in those who had normal renal function. But in those who had renal insufficiency there was significant change of Scr and Ccr after angiography.(3) Among 74 patients had normal renal function,2 patients experienced CIN and the incidence of CIN was 2.7%.Among 11 patients had renal insufficiency,3 patients experienced CIN and the incidence of CIN Was 27.3%, which Was significantly higher than those who had normal renal function (P＜0.05).(4) Among those 5 patients who experienced CIN, the levels of Scr and Ccr in 4 patients returned to pre-angiography level on the seven day.1 patient came to chronic renal insufficiency.Conclusions:The incidence of CIN in patients who had renal dysfunction previously is higher than that in other patients. pre-existed renal dysfunction are independent risk factors of contrast-induced nephropathy. The prognosis of CIN is tolerable.