| Objective: Through the first clinical visit of 370 cases of HIV/AIDS, find the co-relationships on epidemic and dermatologic characteristics, immunological status of HIV/AIDS infection. To provide basic references for physicians on prevention and treatment of the disease.Method: 370 HIV/AIDS patients were included in this study, who choosed in the first affiliated hospital of GuangXi Medical University from January 2000 to October 2009. Clinical data were collected from the history records, include: epidemiological data, clinical manifestations, laboratory data, and so on. All data values were established a database by EXCEL, and then drew a conclusion by SPSS13.0.Result:1.clinical epidemiological characteristics:①Gender and Age: 281 males patients (75.9%), 89 female patients (24.1%), the ratio of male and female HIV/AIDS patient is 3.16:1; age of onset in 5 months to 90 years old, with an average age of 43.18±15.41. Their were 237 patients (64.05%) in 20-50 years old, and 124 patients (33.51%) beyonded 50 years old.②Professional: It concerned more than 11 Professional in HIV/AIDS patients, such as: 141 farmers (38.1%); 65 unemployed people (17.6%); 42 workers (11.4%); 30 individuals (8.1%); 29 cadre (7.8%); 20 Retirement (5.4%); 19 drivers (5.1%); 14 teachers (3.8%); 5 Police (1.4%); 4 medical personnel (1.1%); and 1 college students (0.3%).③Case source: Including all the cities and counties in Guangxi. The top five districts are Chongzuo 71 cases (19.2%), Nanning, 66 cases (17.8%), Guigang 39 cases (10.5%), Liuzhou, 35 cases (9.5%), the guests 32 cases (8.6%).④National: Han 243 cases (65.7%); Zhuang, 123 cases (33.2%); Dong 2 cases (0.5%); Yao 2 cases (0.5%). National Case / ethnic populations: Han 243/30,750,000 = 7.9/100,000, Zhuang 123/16,000,000 = 7.7/100,000;the ratio of male and female HIV/AIDS patient in Han is 3.12:1, and Zhuang is 3.56:1. The patients who were 20-60 years old dominated in the two ethnic groups. There are no significant difference in incidence, gender and age distribution between the two ethnic groups.⑤Transmission: Sexual transmission has become the main transmission channel, including extra-marital sex 50.8%; couples spread 11.1% . Vertical transmission 2.16%; infection through blood contamination is 4.1%; intravenous drug 8.6%.⑥HIV/AIDS patients increased year by year at our hosipital in this 10 years. 357 patients of HIV/AIDS (96.5%) were first diagnosed in our hospital.⑦Clinicians have found that, the percentage of the new cases discovered in all the hospitalizations was: 0.01% in 2000, 0.035% in 2001, 0.040% in 2002, 0.049% in 2003, 0.062% in 2004, 0.072% in 2005, 0.101% in 2006, 0.191% in 2007, 0.116% in 2008, 0.099% in 2009. There were a variety of clinical symptoms with all the inpatients who involved in 28 departments, 306 cases in medicine departments (82.7%), 64 cases in surgery departments (17.3%). The top five sections are Respiratory Medicine, Gastroenterology, Infectious Diseases, Dermatology and Neurology. 114 cases of first diagnosed caused by respiratory disease (30.8%), 62 cases by Digestive disease (16.8%), 30 cases by Dermatology disease (8.1%). Besides, 288 patients (77.8%) have variety of skin lesions during treatment; 315 patients have varying degrees of fever; 321 patients (86.8%) were suffered from weight loss, fatigue, anorexia.2. The relationship of Dermatology, Venereology and immune status⑴. Type of Dermatology and Venereology: 304 patients have suffered from 50 kinds of skin and venereal disease, divided into:①199 cases of Infectious skin diseases, Median count of CD4~+T lymphocyte is 9.94/μl.②78 cases of Inflammatory skin diseases, Median count of CD4~+T lymphocyte is 8.02/μl.③6 cases of tumor skin diseases, Median count of CD4~+T lymphocyte is 31.09/μl.④101 cases of other skin diseases, Median count of CD4~+T lymphocyte is 10.71/μl. There is no significant difference between four groups with the Lymphocyte count, F=0.91,P=0.436. Infectious skin diseases caused by the fungus is the most common, there were 183 cases (49.5%), in which penicilliposis marneffei of a high incidence, 57 cases (15.4%).⑵. Patients often have a serious immune deficiency during the first diagnosing, the Median count of CD4~+T lymphocyte of all the patients is 12.26/μl, 78.09% of them CD4~+T Lymphocyte count less than 50/μl, 93.26% of them CD4~+T Lymphocyte count less than 200/μl; patients have suffered from many kind of opportunistic infections and diseases at the same time.⑶. The level of CD4~+T lymphocyte count is negatively correlated with the skin disease incidence and number of species.Conclusion:1. There are new features of clinical epidemiology: although the number of youth patient was primary (64.05%), the number of elderly patients increased relatively. Patients come from all the cities and counties in Guangxi. The number of farmers was the most. Sexual transmission has become the main transmission channel. HIV/AIDS is now transmitting from highly infected people to general public. Patients have increased year by year in this 10 years. There are no significant difference in incidence, gender and age distribution between Zhuang and Han. Many patients were found though the clinical diagnosis and treatment. It suggest than clinicians are the important force in AIDS preventing and controlling. As the patient's symptoms and clinical manifestations vary, accentuation learning and timely screening of HIV are essentially.2. The level of CD4~+T lymphocyte count is negatively correlated with the skin disease incidence and number of species. Feature of dermatology and venereology with HIV/AIDS is very special. We will make the early diagnosis and infection stages if we can in control of the characteristic. And it helps us to evaluate the effects of anti-viral treatment.3. Infectious skin diseases caused by the fungus is the most common, especially mycodermatitis and penicilliposis marneffei. Those diseases can help us detecting HIV/AIDS early and to prevent the spread of the epidemic.
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