The Association Of A118G Genetic Polymorphism Of μ-opioid Receptor Gene (OPRM1) On Opioid Analgesics Pharmacokinetics After Surgery: A Meta-analysis

Objective:To investigate the potential association among opioid analgesics requirement and pain tolerance and A118G genetic polymorphism ofμ-opioid receptor gene (OPRM1) after surgery.Methods:According to study criteria, literature searching was conducted in Pubmed, Embase and ISI Web of Science to identify studies published before Feb.28,2010. We used meta-analysis to examine the association.Results:This meta-analysis included 8 studies with 1552 patients. Patients with the A allele required less opioids analgesics than with the G allele of the A118G single nucleotide polymorphism (SNP) (P0.05, weighted mean difference (WMD) with 95% CI passed the zero line).Conclusion:Our meta-analysis of available studies indicated that the OPRM1 A118G polymorphism was associated with a significant variability in response to opioid analgesics, rather than pain tolerance, with patients receiving treatment for postoperative pain.