| ObjectiveObserved early changes in CT perfusion parameters before and after chemotherapy in patients with lung cancer to determine the early changes in CT perfusion parameters associated with chemotherapy efficacy.Methodsproceeding routine CT perfusion scan perspectively on 25 path--ologically confirmed and initiating treated lung cancer patients. Use of non-ionic contrast agent 40ml, injection rate 6.0 mL/s, delay 6 s, scan time 53 s. the second CT perfusion scan should be done before the second Chemotherapy. Effect of 25 patients underwent evaluation and follow-up, using the fourth course of chemotherapy, CT images compared with the original image, according to RECIST criteria were divided into remission group and non-remission group. We compared blood flow BF, blood volume BV, Patlak vascular permeability PS, Patlak blood volume PBV in all groups before and after treatment difference in change. Using SPSS 17.0 software for statistical analysis, normality testing at first, followed by paired t test, P<0.05 is believed as having statistically significant. Statistical difference between the last two groups of data were done to alleviate the effect associated with the non-remission assessment and using X2 fourfold table analysis to test the the relationship between early CT parameter changes and the effects of chemotherapy.Result27 patients, the success of 25 cases,15 cases of remission,10 cases of non-remission group. Changes in CT perfusion parameters in the early stages of lesion size change was not statistically significant. The whole group the average pretreatment lesion size (maximum diameter of the tumor maximum dimension measurements, following the same) 4.06±1.18 cm, after treatment 3.86±0.97cm, t value of 1.726, p value of 0.097; remission group pretreatment lesion size of 4.01±1.25cm and after treatment,3.86±1.70cm, t value of 1.068, p value of 0.303; non-remission group pre-treatment lesion size of 4.14±1.12cm, after treatment 3.87±0.85cm, t value of 0.211, p value of 0.211.However, CT perfusion parameters before and after treatment have changed, in which remission group BV, PBV parameter values before and after treatment (respectively,71.0±20.4,49.8±31.4,73.1±34.1,45.2±19.0, t value of 2.558,3.325, p value of 0.023,0.005) with statistical significance, and the two parameters can be seen a downward trend; non-remission group BV, PBV parameter values before and after treatment (respectively 50.4±61.0,120.5±15.7,38.0±9.3, 62.0±38.3, t value of-3.062,-2.471, p values of 0.016,0.036) also has a statistically significant difference, showing an upward trend; to divide the control BV and PBV remission rate of increase in X2 examination certification BV group and lower group no significant difference in remission rate, PBV 1 decline in the high group and the group was statistically significant difference in remission rates, PBV lower remission rate was higher than PBV elevated group.ConclusionWith CT perfusion parameters change in the early stages, lesion size change was not statistically significant. after chemotherapy, CT perfusion parameters of remission group declined, no-remission group upward, in which BV, PBV changes of significant meaning; early CT perfusion values of PBV have a certain effect to assess the effects of chemotherapy:the early stage after chemotherapy, PBV increase shows that poor drug effects and is not sensitive to chemotherapy drugs; PBV reduction shows that good drug effects and is sensitive to chemotherapy drugs.
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