The Effect Of Chinese Herbs Which Can Strengthen Spleen And Remove Eczema On Body Mass Index And Sera Hormone Concentration In Patiens With Polycystic Ovarian Syndrome Of The Phlegm-damp Type

BackgroundPolycystic Ovarian Syndrome is a common endocrine disease relate to reproduction and abnormal metabolism, and it's one of the most common pathogeny which can result in women's menstrualdisorder and anovulatory infertility during the period of duration. Polycystic Ovarian Syndrome patients had a disorder of endocrine and metabolism, which mainly including the incerasing ratio of LH and FSH, HT, HI, HIR and MS, etc. Since the 1970s, the diagnosed basis of Polycystic Ovarian Syndrome was emphasized the disorder of biochemical and endocrine area, not only the morphologe and histology of ovary. At present, the endocrine and metabolic disorder of Polycystic Ovarian Syndrome patients becomes a research highlight.PurposeTo explore the preliminary mechanism of the Phlegm-damp type Polycystic Ovarian Syndrome patients treated with Chinese herbs which can strengthen spleen and remove eczema, and to provide reference for clinical application, this subject is supposed to treat the Phlegm-damp type Polycystic Ovarian Syndrome patients with Chinese herbs which can strengthen spleen and remove eczema, and observe their BMI and Sera hormone concentration be-and-af the treatment.Patients and Methods Collect 30 Polycystic Ovarian Syndrome patients from gynecology outpatient department of the first Affiliated Hospital of Guangzhou Univercity of Chinese Medicine during October 2008 to February 2010, aged 18-40 years old, and syndrome differentiated of the phlegm-damp type. The Chinese herbs which can strengthen spleen and remove eczema is based on Chenxia Liujun tang. Judging the patient's menstrual cycle from her BBT, jiajian the decoction as the change of menstrual cycle and clinical syndromes, and treating for 3 months. Observed their BMI and sera hormone concentratio be-and-af the treatment. All datum use the statistical software SPSS11.5, and difference analysis using t-test.Results1, Both weight and body mass index were decreased after the treatment, and the values had extremely significant difference (P<0.01).2, Sera follicle-stimulating hormone (FSH), luteinizing hormone (LH), the ratio of LH and FSH (LH/FSH) and testoterone (T) were all decreased after the treatment. The changes of LH, LH/FSH and T were extremely significant differenced (P<0.01), and the change of FSH was just significant difference (P<0.05).3, Sera estradiol (E2) was increasd after the treatment, but progesterone (P) and prolactin (PRL) were decreased. All of them had no significant difference (P>0.05).4, After the treatment,1 patient was healed,7 patients had good effect, 18 patients had effect and only 4 patients had bad or no effect. So the overall efficiency was 86.67%.Conclusion1, The Chinese herbs which can strengthen spleen and remove eczema can improve body mass index of patiens with Polycystic Ovarian Syndrome of the Phlegm-damp type.2, The Chinese herbs which can strengthen spleen and remove eczema can improve two important clinicopathological features, namely the incerasing LH/FSH and HT, in patiens with Polycystic Ovarian Syndrome.