The Relation Of Serum High-sensitive C-reactive Protein To Risk Factors And Target-organ Damage In Hypertensive Patients

Objective:To provide a theoretical basis for evaluating the severity and prognosis of hypertension,we explore the relation of high-sensitive c-reactive protein (hs-CRP) to risk factors and target organ damage in hypertensive patients.Methods:Serum hs-CRP concentration of 216 hypertensive cases and 36 healthy subjects were tested. They were divided into different groups according to the associated diseases, the number of involved target organ and the difference of involved target organ. Hs-CRP and other variables such as TC, TG, LDL, BUN, Cr, FBG, LVMI, SBP and DBP were compared. The relativity between variables such as TC, TG, LDL, BUN, Cr, FBG, LVMI, SBP and DBP and hs-CRP was analyzed by using of linear correlation analysis and multiple linear regression analysis.Results:1. Hypertensive patients had significantly higher of smoking, TC, TG, LDL, BUN, Cr, FBG, LVMI, SBP, DBP and hs-CRP than healthy subjects (P<0.01).while HDL was lower in hypertensive patients(P<0.01).2.Compared with merely hypertension, hypertensive patients complicated with diabetes mellitus and CHD had significantly higher of TG, TC, LDL, BUN, Cr, FBG, LVMI, DBP and hs-CRP. The hs-CRP levels in hypertensive patients complicated with CHD group were higher than those complicated with diabetes mellitus.3.Correlation analysis showed hs-CRP levels had a positive correlation with the number of damaged target-organ. Following damaged target-organs increasd, hs-CRP levels also gradually increased. The correlation coefficient was 0.747 (P<0.01) 4.Among the different involved target organ groups, hs-CRP in left ventricular hypertrophy, carotid atherosclerosis and renal injury group was obviously higher than retinopathy group. Hs-CRP in left ventricular hypertrophy group was significantly higher than carotid atherosclerosis and renal injury group. There is no obvious difference between carotid athero-sclerosis and renal injury group.5.Hs-CRP was positively correlated with age, SBP, DBP, FPG, TG, TC, LDL, BUN, Cr and LVMI, and negatively correlated with HDL. Stepwise regression analysis showed that the dominated factors of hs-CRP concentrations levels were left ventricular mass index, HDL and age. The Regression equation was:y=1.276+0.007a-0.397b+0.007c, y representative of logarithmic after transformation of hs-CRP, a representative of left ventricular mass index, b representative of HDL, c representative of the age.Conclusion:Hs-CRP levels of hypertensive patients were significantly higher than healthy subjiects. The more number of involved target organ, the higher serum hs-CRP levels were. Patients with different involved target organ had different inflammatory degree, which hypertensive patients with LVH had the highest hs-CRP levels while retinopathy group had the lowest. Hs-CRP was positively correlated with age, SBP, DBP, FPG, TG, TC, LDL, BUN, Cr and LVMI, and negatively correlated with HDL. Stepwise regression analysis showed that the dominated factors for hs-CRP levels were LVMI, HDL and age.