The Study Of Ascending Aortic Elasticity In Patients With Uremia By The Strain Rate Imaging

Objective:To explore the value of strain rate imaging in assessing ascending aortic elasticity in patients with uremia.Methods:A group of 30 healthy adults were enrolled in normal controls (group A).40 patients with uremia were divided into two groups by Left ventricular mass index,22 patients in the group with non-hypertrophic left ventricle (group B) and 18 patients in the group with hypertrophic left ventricle (group C). Collect the systolic blood pressure(SBP), diastolic blood pressure(DBP), pulse pressure(PP).AND the three groups were undertaken conventional echocardiography exam and strain rate imaging exam, the parameters were measured included:diastolic interventricular septal thickness(â…£STd), diastolic left ventricular diameter(LVDd), diastolic posterior left ventricular wall thickness(LVPWTd), aorta systolic diameter (Ds), aorta Diastolic diameter (Dd).Then aortic stiffness index and distensibility were calculated using formulas. To analysis the motion of posterior wall in ascending aortic of the the three groups by the strain rate imaging (SRI).Measured the strain rate of early diastolic strain rate (SRe), later diastolic strain rate(SRa) and systolic peak strain rate(SRs) of their posterior wall in ascending aortic.And also measured the indexes of the tissue velocity imaging (TVI) such as velocity of early diastolic (Ve), velocity of later diastolic (Va), velocity of systolic (Vs)Results:1.SBP:The group B and group C were higher than the group A(P<0.05).PP:The group C was higher than the group A(P<0.05). The parameters of the other groups were no more statistical significance.2. IVSTd,LVPWTd:The group C was higher than the group A and the group B (P<0.05). LVMI:The group C was significantly higher than the group A (P<0.01) and the group B (P<0.05). Ds,Dd:The group C was higher than the group A(P<0.05).The stiffness index of the group B and group C were higher than the group A(P<0.05),the distensibility of the group B and group C were lower than the group A(P<0.05). The parameters of the other groups were no more statistical significance.3. SRe,SRa:The group B and group C were lower than the group A(P<0.05). SRs:The group C was significantly lower than the group A (P<0.01) and the group B (P<0.05), the group B was lower than the group A(P<0.05). Ve,Va:The group C was lower than the group A(P<0.05). The parameters of the other groups were no more statistical significance.Conclusion:1.Strain rate imaging can reflect the changes of aortic elasticity sensitively.2.The ascending aortic elasticity in patients with uremia decreased, the changes that was earlier than the changes in left ventricular and aorta reconstruction, and further reduce worse.3.The changes of ascending aortic elasticity in uremic patients was another factor to cause left ventricular hypertrophy besides the blood pressure.