The Clinical Study On The Protective Effects Of Sodium Ferulate In Vascular Endothelial Function During Cardiopulmonary Bypass

Objective:Cardiopulmonary bypass is generally used to perform surgical correction of congenital heart disease (CHD).Cardiopulmonary bypass(CPB) and related ischemia reperfusion injury results in generalized endothelial cell injury. To preliminary study the protective effects of Sodium Ferulate in vascular endothelial function during cardiopulmonary bypass by observing the change of vascular endothelial cell (CEC),nitric oxide (NO) and endothelin-1 (ET-1) in children with congenital heart disease.Method:Sixty patients with congenital heart disease were randomly divided into two groups:Sodium Ferulate group (group S,n=30),and control group (group C , n=30 ).Sodium Ferulate (8mg/kg) were given intravenously before CPB ,blood samples were taken simultaneously from arterial line before CPB(T0),bypass 30min (T1), the termination of CPB (T2), after 2hrs operation( T3)and after 6hrs operation(T4) respectively for determination of blood concentration of vascular endothelial cell(CEC),plasma concentration of nitric oxide (NO)and endothelin-1 (ET-1).Results:The difference of the two groups were not statistically significant at T0(P>0.05). The level of CEC significantly elevated after CPB in both two groups( P<0.05),The levels of CEC were lower at T2 in group S than in the group C ( P<0.05);NO was decreased in both two groups,but higher in the group S than in the group C at T2,T3,T4( P<0.05 or P<0.01);While in group S and group C the concentration of plasma ET-1 did not have significant difference before CPB,a slight decrease in the concentration of ET-1 in both two groups at T1,and then were found significantly increase ( P<0.05).But lower in the group S than in the group C at T1,T2,T3,T4( P<0.05 or P<0.01)Conclusion:There were severe endothelial cell damage during Cardiopulmonary bypass (CPB),may result in the loss balance of nitric oxide (NO) and endothelin (ET).Sodium ferulate can effectively antagonize the secretion of ET-1 to promote the formation of NO,it is a obvious effect in reducing CPB-induced endothelial cell damage.