Pharmacokinetic Interaction Between Warfarin And Aspirin In Rats

Objective: To study the pharmacokinetic interaction between warfarin and aspirin in rats.Method: The rats were divided into non-steady-state group (single-dose group) and steady-state group (multi-dose group), each were randomly divided into three groups, namely, warfarin group (0.2mg/kg), aspirin group (10mg / kg), warfarin (0.2mg/kg) + aspirin group (10mg/kg), n = 6, the rats were fed continuously for six days, in the first day and sixth day of a multiple Point in time sampling, analysis of plasma concentration-time curves and pharmacokinetic parameters.)Results: With aspirin-compartment model with a description of the data, warfarin use two-compartment model described the data. Under the non-steady-state and steady-state, aspirin alone and combined with the plasma concentration-time curves are similar between the pharmacokinetic parameters was no significant difference; in the non-steady state, with warfarin alone and in combined with the plasma concentration-time curves is similar, but in steady state, together with the blood concentration-time curves was significantly higher than when the curve alone, pharmacokinetics calculation results also show that, when combined with the AUC and Cmax single When compared with the larger, and there is statistically significant.Conclusions: When warfarin and aspirin combined with steady-state, the aspirin warfarin pharmacokinetic parameters affect warfarin increases the exposure (AUC and Cmax). Tip of the two drugs used together, there are likely to increase the warfarin bleeding tendency, when combined with clinical medicine should pay attention to therapeutic drug monitoring.