Preparation And Study Of Alfuzosin Hydrochloride Orally Disintegrating Tablets

With the development of people's quality of life and health level, population aging has become a trend. The rate of Benign Prostatic Hyperplasia (BPH) is increasing, which becomes a very difficult question of current society. Research of finding new methods to cure this disease is going on, and a new al adrenoreceptor blocker manufactured by France LABORATOIRES SYNTHELABO, alfuzosin can lower urethral tension and improve urine flow by blocking the al adrenoreceptor in bladder neck, capsula prostatica, prostate and urethra.Orally disintegrating tablets (ODT) is a new dosage for oral administration. When taking ODT, you need little or no water and chewing is unnecessary. Just place it on your tongue and it will disperse and dissolve in saliva. Then the drug is absorbed in mouth and esophagus, which results in higher bioavailability and reduced first pass effect. ODT can rapidly dissolve in saliva within seconds or disintegrate in mouth quickly, which is appropriate for children, old people and patients in bed.This study optimized the formula of alfuzosin tablets, chose appropriate process after screening, prepared alfuzosin orally disintegrating tablets and discussed the formula and process. The optimal formula includes PVPP 10mg, mannitol 50mg, MCC 30mg,0.6percent of magnesium stearate,1.2 percent of silicon dioxide,0.5 percent of aspartame and 0.5 percent of sweet orange essence.Dissolution in vitro of alfuzosin orally disintegrating tablets was analyzed. Investigation of taste, friability, disintegration time and dissolution demonstrated its pharmaceutical usage and it will be used widely.