Analysis Of Surgical Resection Combined With Hepatic Artery And Portal Vein Infusion Chemotherapy In The Treatment Of Primary Liver Carcinoma

Objective:To evaluate clinical efficacy of surgical excision combined with regional infusional chemotherapy in the treatment of primary liver carcinoma.Methods:126 cases of primary liver carcinoma from January 2004 to December 2008 treated by surgical excision combined with hepatic artery and portal vein chemotherapy pump implantation intraoperation, postoperative combined with tegafur, DDP Regional infusion chemotherapy in 4 to 6 cycles. Dynamic monitoring of recurrence by AFP and colorful B-ultrasonography, the recurrence re-operation or radiofrequency treatment. To analysis surgical approach patients with liver cirrhosis, tumor extent. Evaluated follow-up survival period and relapse rate.Results:The HBV infection rate 79.4%, HCV infection 1.6%.96 patients with liver cirrhosis,76.2%; liver function Child-pugh B 19 cases (15.1%). Large hepatocellular carcinoma and giant blocks of hepatocellular carcinoma in 110 cases (87.3%), tumor involving more than one liver segment 86 cases (68.2%), involving major blood vessels 41 cases (32.5%). Semi-hepatectomy 18 cases (14.3%), multiple hepatic resection 71 cases (56.3%), jump around the liver resection in 10 patients (7.9%), special parts of the liver resection in 10 patients (7.9%), portal hypertension with splenomegaly Large splenectomy 9 cases. 126 patients with an average survival time 31.1±2.4 months (6 to 70 months). 1,3,5 year survival rates were 97.6%,84.9%,79.4%.1,3,5 year recurrence rates were 3.2%,21.4%,28.6%. Recurrence of hepatocellular carcinoma cured 7 cases of re-operation, RFA in 2 cases.Conclusion:Patients infected with hepatitis, cirrhosis and cancer lesions wide are adverse factors for surgical resection. Improve surgical method,joint comprehensive measures to prevent recurrence could enable the large liver,giant blocks of liver cancer gain cured opportunities. Hepatic artery and portal vein regional infusion chemotherapy can be used as conventional method to prevent recurrence after operation. Resection and hepatic artery and portal vein regional infusion chemotherapy can help reduce the rate of recurrence and improve survival date. To take effective monitoring of recurrence after hepatectomy, early diagnosis, early treatment is conducive to further improve the prognosis of HCC...