| Objective and Background: Epilepsy is the most common and serious neurology paroxysmal disease worldwide. In recent years, the prevalence of epilepsy showed the trend continued to rise, and affecting about 1% world's population. In most patients with epilepsy, in addition to frequent, irregular seizures, the impairment of the cognitive function is also more common. No less than 30% -40% of epileptic patients with cognitive dysfunction, and has also been reported at between 21% -67%. So far oral anti-epileptic drugs is the primary means of epileptic treatment. The pharmacological mechanism of anti-epileptic drugs is to control the abnormal discharge of brain neurons. meanwhile its control seizures, improve cognitive function, it may also lead to new impairment of the cognitive function. A large number of studies have reported the affecting of the traditional antiepileptic drugs (AEDs) on cognitive function, and more conclusions are consistent. At present, the neo-type antiepileptic drugs have reported a wider clinical application, and basic level study about the adverse effects on cognitive function is still rare. In this study, applying penicillin animal model of epilepsy, comparing oxcarbazepine (OXC), levetiracetam (LEV), lamotrigine (LTG) the affect on cognitive function in epileptic rats, thus guiding the clinical neo-type antiepileptic drugs applications.Methods: First, experimental animals are tested in the Morris water maze, and excluding the rats with cognitive disorders. the remaining animals were randomly divided into groups. Model group and model drug group were prepared epileptic animal models make use of injecting Intraperitoneally of penicillin. Kindling effect depends on EEG records and Racine classification criteria. After the success of animal models, every group animals are fed different antiepileptic drugs in Gavaging for two weeks. The Morris water maze is re-used to test the learning and memory function in experimental animals.Results: The epileptic model rats by intraperitoneal injection of penicillin after 8-10 times begin to appearance 1-2 Grade seizures, and continue intraperitoneal injection of penicillin to 12-16 times, according to Racine classification experimental animals'epileptic seizures gradually increase to full kindling; EEG recording of epileptic model rats Amygdala can observe distributed epileptic waves (sharp waves, spikes, spike - slow wave, sharp - slow-wave complex) between the period of epilepsy. The results from the Morris water maze test: normal rats results increased rapidly, escape latency successive-by-day decrease. model drug group rats results slightly slower than the normal group, but Results no significant difference. in the test of Length of stay in the platform quadrant and the number of cross platform quadrant, the results of each group rats has no not obvious difference.Conclusion: The epileptic animal models by intraperitoneal injection of penicillin can be safe and effective kindling method. Achieving the full kindling effect about 12-16 days, after an incubation period of 10-15 minutes, 60 minutes for seizures; penicillin kindling model of cognitive function in rats no obvious adverse reaction; EEG recording of model rats Amygdala can observe 7-9Hzα,βwaves, no epileptiform discharge. Model group can be seen distributed Amygdala epileptic waves(sharp waves, spikes, spike-slow wave, sharp-slow- wave complex). Neo-type antiepileptic Drugs(oxcarbazepine, levetiracetam, lamotrigine) on the effect of cognitive function in penicillin kindling effects rats no significant adverse reactions, the tolerance of drugs was good.In recent years, Neo-type antiepileptic Drugs in the treatment of epilepsy has greatly shown its superiority comparing with the traditional antiepileptic drugs. Nevertheless, the clinical application of these new drugs has a short time, the lack of systematic, large-scale clinical and basic research, its impact on the cognitive function of epilepsy patients remains to be further in-depth observation.
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