The Clinical Features And Prognostic Factors Of DLBCL And Its Significance

Objective:To explore the clinical features of diffuse large B-cell lymphoma(DLBCL) in Chinese patients, and analyze the prognositic significance of Ann Arbor stages, serum lactate dehydrogenase(LDH),β2-microglobulin(β2-MG) with DLBCL cases.Methods:One hundred and one patients who were diagnosed as DLBCL by pathology form March 2003 to November 2008 in First Affiliated Hospital, College of Medicine, Zhejiang University were enrolled and analyzed retrospectively. All of the cases were determined according to WHO 2001 classification, and followed up by telephone. Collected the level of serum LDH,β2-MG, and clinical stages, the patients were analyzed the relation between these parameters and survival.Results:1) Firstly, among the 101 de novo DLBCL patients, the average age was 49, the ratio of male to female Was 1.29:1. Fifty patients were older than 50, accounting for 49.5%. Forty-six cases (45.5%) were found firstly in lymph node and 23 cases (22.8%) in the gastrointestine, especially in ileocecus and stomach. Thirty-two patients had B symptoms, accounting for 31.7%.2) Among 85 followed-up cases during the median 31-month follow-up,36 (42.4%) died of DLBCL;and 17 cases (20%) passed away in the first year after diagnosis.3) In this study, the rate of mortality was significantly higher in elevated LDH group than in normal group. On the other hand, the overal survival rate was lower in the abnormal group of LDH level (P<0.05).4) The serumβ2-MG level were significantly higher in the cases with stage III and IV than stageⅠandⅡ(P＜0.05).Conclusions:1) In DLBCL cases, the elevated LDH level could be a poor prognostic factor and be associated with clinical staging.2) The level of serumβ2-MG might also be associated with clinical staging and survival.