The Influence On MAC-awake Of Sevoflurane By Sacral Block In Children

ObjectivesTo investigate the influence on MAC-awake of sevoflurane by sacral block in children.Methods60 patients (2-8years old)undergoing urogenital surgery were randomly allocated to receive general anesthesia group (groupâ… ,n=30) or combined general-sacral block anesthesia group(groupâ…¡,n=30).The patients were premedicated with intramuscular atropine 0.01mg/kg 30 min before anesthesia. In groupâ…¡, we used inhalation combined with sacral block(0.25% Ropivacaine 1 ml/kg). All patients keep respiration without intubation. Anesthesia was maintained with sevoflurane, at the end of surgery, a predetermined end-tidal sevoflurane concentration was maintained for at least 10 min before a standard stimulus was applied and an observer determined if the child was awake. The Dixon up-down method was used to determine the progression of subsequent concentration, the MAC-awake(ED50) for the two groups were obtained using the probit model.ResultsThere was no statistical difference in age, sex ratio, weight, surgery time and duration of anesthesia(P>0.05). This study found evidence for a difference in MAC-awake(ED50) between the two groups, the MAC-awake of sevoflurane in groupâ…¡(0.39%) was less than that in group I(0.62%)(P< 0.01).ConclusionsThe MAC-awake of sevoflurane can be reduced by sacral block in children.