Research On The MRI And Related Factors In The Preterm Infants With Early Cerebral White Matter Damage

ObjectiveTo assess the early changes of MRI and its clinical significance in the preterm infants with the cerebral white matter damage(CWMD),based on the dates offered by MRI, and investigate the related factors.MethodsThe research was prospectively performed on 262 preterm infants from September 2007 to September 2009 at the neonatal ward of the Shengjing Hospital of China Medical University. All performed MRI examination in 7 days,subjects were classified into two groups according to MRI diagnostic criteria:case group and control group.of case group,29 were followed up..ResultFocal injury,high signal appeared on DWI,with normal or slightly high signal on T1WI,accompanying low or normal signal on T2WI.The diffuse injury,diffusive high signal only on DWI, no abnormal signal on regular MRI. after about two weeks,focal lesions have been shown in two ways:lesion vanished;normal or slightly high signal on DWI, while on T1WI high signal and low or normal signal on T2WI,diffuse injury have been change into periventricular leukomalacia(PVL),High signal or miscellaneous (high and low)signal on T2WI,while on T1WI and DWI, miscellaneous signal;related factors were analyzed.Univariate analysis, perinatal infection, twins, hypocalcaemia, metabolic acidosis, hypoxia, mechanical ventilation and infants infection for preterm CWMD were considered statistically significant. LogisticRegression analysissitus, perinatal infection, hypoxia and intrauteral embarrassed risk factors for preterm infants with CWMD.Conclusions DWI can detect the lesions in early stage of CWMD;the interaction of multiple factors includes the premature infant CWMD, perinatal infection hypoxia and intrauteral embarrassed have close relationship whith the CWMD;there are not specific clinical manifestations of CWMD,so suggesting MRI should be performed as a routine in preterm infants,and followed up if abnormal signal appeared.