The Correlation Between Fraction Of Exhaled Nitric Oxide And Lung Function In Asthmatic Children

ObjectiveTo investigate the clinical significance and the correlation between exhaled nitric oxide and lung function (FEV1,FEV1/FVC and PEF) in asthmatic children of non-acute exacerbation.MethodsFifty three asthmatic children of non-acute exacerbation aged 5 to 14 years old were recruited from ShengJing Hospital of China Medical University. According to whether the patients were treated with inhaled corticosteroid (ICS) therapy regularly, they were divided into two groups:steroid group and non-steroid group, then the fraction of exhaled nitric oxide (FeNO) and lung function were measured.20 healthy children from Teng Fei primary school were also measured as control group.ResultsIn non-steroid group, the levels of FeNO (mean 40.45±25.43 parts per billion) were significantly higher than those in the steroid group (mean 19.88±13.85ppb) and control group(mean 8.85±3.57ppb), and they were statistically significant. (P<0.05). The mean FEV1 in steroid group was (95.15±8.99)%, and the mean FEV1 in no-steroid group was (91.35±11.69)%. There were no significant differences between two groups (P>0.05). Significantly negative correlation·was found between FeNO and FEV1 in non-steroid group (r=-0.59, P<0.05),but there was no significant correlation between them in other two group (P>0.05)ConclusionThe levels of FeNO were higher in non-steroid group than those of the steroid group in asthmatic children of no-acute exacerbation. FeNO may be a good biomarker to evaluate the airway inflammation of asthmatic children.