Expression Of VEGF, EGFR And P53 In Colorectal Cancer Tissues And Correlation

ObjectiveTo study the correlation of VEGF,EGFR and P53 expression in colorectal cancer tissues and their significances to clinicopathologic character. Study the mechanism of the there in promoting tumor growth in colorectal cancer and the correlation.MethodsWe studied the expression level of VEGF, EGFR and P53 in 85 cases of colorectal cancer using immunohistochemical S-P method, and analyzed the relationship between clinicopathologic factors and to explore the linkages among the three.ResultsThree in colorectal cancer tissues with positive expression rate of lymph node metastasis, peritoneal or distant metastasis, depth of invasion, tumor differentiation degree of significant relationship (P<0.05); but not correlated with the patient's sex, age and tumor position (P> 0.05). VEGF and EGFR expression was correlated, The Pearson coefficient of continency is 0.27 (P<0.05);VEGF and P53 expression was correlated, The Pearson coefficient of continency is 0.50 (P<0.05);EGFR expression was not correlated with P53 (P>0.05).ConclusionVEGF, EGFR, and P53 protein expression are closely related with invasion and metastasis of colorectal cancer; analysis of their expression can enhance the sensitivity of cancer detection, and enhance the evaluation of patients with colorectal cancer survival and prognosis, targeted therapy to provide scientific citation.