Effect Of Mono Anti-platelet And Dual Anti-platelet Therapy On The Prognosis Of Patients With Acute Coronary Syndrome

Objective:To observe the different effect of mono anti-platelet and dual anti-platelet therapy on the prognosis of patients with acute coronary syndrome (ACS). It may provide evidence for the standard treatment in community hospital.Methods:28 patients with ACS who refused percutaneous coronary intervention (PCI) operation were randomly divided into two groups (A/B). each group involved 14 patients. Patients in group A took both Aspirin and clopidogrel as dual anti-platelet treatment and patients in group B only took Aspirin as mono anti-platelet treatment. Echocardigoraphy examination was performed every three months. Cardiovascular and cerebrovascular events including recurrent myocardial infarction, cerebrovascular accident, rupture of ventricular aneurysm and sudden cardiac death were observed in 12 months.Result:7 cases's cardiac function in group A improved more than 1 degree and 2 cases improved more than 2 degree.3 cases's cardiac function in group B improved more than 1 degree and 1 cases improved more than 2 degree. The differences is significant between 2 groups by chi square test (P<0.05).1 case of recurrent myocardial infarction occured in group A in one year.3 cases of cardiovascular events occured in group B in one year. Among them,1 case is recurrent myocardial infarction and another 2 is cardiac death. The differences is significant (χ2=7.23, P<0.05)Conclusion:On the basis of regular therapy, combined using of Aspirin and clopidogrel as dual anti-platelet therapy may improved cardiac function including data of LVEF (%),CO,E/A. Dual anti-platelet therapy is better than mono anti-platelet.