Significance Of N-terminal Pro-B-type Natriuretic Peptide In Patients With Acute Myocardial Infarction

Objectives:To evaluate the value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in estimating risk stratification in patients with acute myocardial infarction (AMI) and to determine the relationship between NT-proBNP and adverse cardiac events after AMI.Methods:The plasma NT-proBNP were measured by echocardiography with Roche NT-proBNP reagent in the Elecsys2010 automatic analyzer at 1-2 days after AMI. The main outcome measure were major adverse cardiac events at 7 days.Results:The plasma NT-proBNP level in A group was significantly higher than that in B group. The plasma NT-proBNP level of the patients with AMI decreased significantly after PCI. There were significant different between the different ventricular dysfunction.The plasma NT-proBNP level negatively correlates with left entricular ejection fraction (LVEF) in patients with AMI (r=-0.84, P<0.001). Patients suffering from heart failure or total major adverse cardiovascular events had higher levels of NT-proBNP than those without (P<0.001).The plasma NT-proBNP level positivly correlates with TNT(Troponin T) (r=0.668,P<0.001)and high-sensitivity C-reactive protein (hs-CRP)(r=0.643,P<0.001) in patients with AMI (r=-0.84,P<0.001).Conclusions:The plasma NT-proBNP level in A group was significantly higher than that in B group. The plasma NT-proBNP level of the patients with AMI decreased significantly after PCI. The Plasma NT-proBNP level negatively correlated with LVEF in patients with AMI.Patients suffering from major adverse cardiovascular events had higher levels of NT-proBNP than those without (P<0.001). The plasma NT-proBNP level positivly correlates with TNT and hs-CRP in patients with AMI.