| Solid lipid nanoparticles (SLN) which was developed in the early 90s , 20th after emulsion,liposomes,microparticles and milimicron particles was a new submicroparticle drug delivery system of good performances. Its size ranges from 10 to 1000mm. It has the advantages of high stability, low leak of drugs, and low toxicity and manufactured on a large scale as well as liposomes and emulsion. SLN is a potential drug delivery system. Flunarizine Hydrochloride (FNZ) was used as a model drug in this paper. It has been prepared into FNZ-SLN to investigate its physicochemical properties in order to study brain targeted aspect of SLN.Stearic acid was used as carrier, granulesten and poloxamer 188 as surfactant to prepare FNZ-SLN by emulsion-evaporation-solidified at low temperature process. To evaluate it mainly by entrapment rate. Separate wrapped and free drugs by Sephadex G-50, determine the entrapment rate and optimize the formula and technique by single factor and orthogonal design.FNZ-SLN which was prepared by the optimum fomula and technique was examined by transmission electron microscope. Its morphology was sphericity or near spherical solid. The mean diameter of the particles was about 140nm, entrapment rate was 81.3±1.53%, drug loading rate was 1.57±0.02%.The physical and chemical stability, pharmacy characteristics of the FNZ-SLN were investigated, and FNZ-SLN release in vitro were preliminary investigated by the index of appearance, size, encapsulation rate. By fitting the release curve we can know the release curve in line with Weibull distribution function.The reference preparation was self-made flunarizine hydrochloride solution.The mice were injected through the tail vein, blooded through eyeball, killed and putted out of their minds and viscera. Making preliminary study of the plasma and tissue distribution. The results show that the FNZ-SLN increased the distribution of FNZ in brain and lung, the DTI of brain is from 1.8 to 5.3, so FNZ-SLN has obvious brain targeting.
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