Clinical Analysis Of 19 Cases Of Multiple Sclerosis And Review Of Literature

Objective To investigate clinical features and treatment points Of multiple sclerosis (MS).Methods Reviewing medical records of ten cases at our hospital over a period of 8 years and combinating with reported literature at home and abroad.Results Age of onset in this group of patients ranged from 18 to 61 years, mean age 35.6 years. Among them,1 patient less than 20 years old. Acute and subacute onset in 14 cases (73.7%), chronic onset in 5 cases (26.3%).5 patients the first attack, relapsing-remitting in 12 cases,2 cases of primary progressive. Initial symptoms:5 cases of vision loss, diplopia in 3 cases, 11 cases of limb weakness, sensory disturbance in 13 cases,4 cases of ataxia, urine will be obstacles in 4 cases,5 cases of dizziness, dizziness associated with nausea and vomiting in 1 case, negative speech 4 cases. Supplementary examination:cerebrospinal fluid, normal pressure in 15 cases,4 cases of CSF protein elevation,17 patients with elevated CSF IgG, oligoclonal bands inspection line 6 cases, abnormal in 2 cases, anti-myelin basic protein examination in 6 cases increased in 4 cases.14 cases evoked potential, VEP abnormalities in 6 cases (42.9%), BAEP abnormalities in 4 cases (21.1%), SEP abnormalities in 9 cases (47.3%), VEP abnormalities in 1 case (16.7%) were subclinical lesions. Magnetic resonance imaging scan,16 cases with cranial MRI scans were abnormal, showing multiple white matter long T1, long T2 punctate, patchy or oval lesion in the periventricular, frontal white matter, brain stem, cerebellum etc..6 cases in which cervical, thoracic MRI, four cases of spinal cord or cords a little bit like lesions. Brain biopsy in 1 case.3 cases were misdiagnosed before admission, were misdiagnosed as cerebral infarction, by improving the relevant auxiliary examination diagnosed as multiple sclerosis. Acute treatment with corticosteroid therapy. Clinical Evaluation of use of EDSS,19 patients were cured in 3 cases, relieved in 11 cases, the total effective rate of 73.7.Conclusion 1. Multiple sclerosis occurs in many young women, detailed history, combined with symptoms, signs, and cerebrospinal fluid, evoked potentials, MRI, etc., and strictly in accordance with the McDonald diagnostic criteria for diagnosis is not difficult.2. For the acute phase of MS steroid pulse therapy is effective and, on remission to prevent relapse is no good treatment.3. Evoked potential, MRI and other tests for early diagnosis of MS has important value.