Study Of Relationship Between Serum Neuron-specific Enolase And Childhood Absence Epilepsy

ObjectiveTo investigate the levels of neuron-specific enolase (NSE) in serum and to explore neuronal damage in childhood absence epilepsy after seizures. To explore the clinical significance of serum NSE in childhood absence epilepsy, To investigate whether the serum NSE can as an biological marker of brain cell damage or not after absence seizures.MethodsTwenty two children with absence epilepsy were enrolled, according to whether the hyperventilation can induce absence seizures or not they were divided into two subgroups: 10 cases of absence seizures group/12 cases of non- seizure group. and twenty healthy children served as normal control group. collected peripheral venous blood 2ml within 30 minutes after absence seizure in 10 cases of absence seizures group, collected peripheral venous blood 2ml within 30 minutes after hyperventilation in 12 cases of non- seizure group. Collected peripheral venous blood 2ml in normal control children of empty stomach at early morning. Enzyme-linked immunosorbent assay (ELISA) was used to detect the serum NSE in each group.ResultsThe levels of serum NSE in children with absence seizures group were 11.65±0.85μg/ L, The levels of serum NSE in children with non- seizure group were 7.29±0.88μg/ L, The levels of serum NSE in children with normal control group were 7.40±1.39μg/ L. The serum levels of NSE in the absence seizures group were significantly higher than those in non- seizure group (P < 0.01). The serum levels of NSE in the absence seizures group were significantly higher than those in normal control group(P < 0.01). but there was no visible difference between non- seizures group and normal control group ( P > 0.05) .ConclusionThe levels of serum NSE in children with absence epilepsy were markedly increased after seizures. suggesting that a certain degree of neuronal damage may result from absence seizures. Neuron-specific enolase may serve as an important specificity of biochemical marker in the early detection of neuronal damage after absence seizures. ObjectiveTo investigate the diagnosis value of magnetoencephalography (MEG) combined with synthetic aperture magnetometry(SAM) analysis in localizing epileptogenic focus of children with childhood absence epilepsy.MethodsSelected thirteen cases who were confirmed with childhood absence epilepsy by EEG features and clinical manifestations, All of the cases accepted the Magnetoencephalography detections, Record the magnetic source signals of resting state and after three minutes of hyperventilation(HV) test, Select 20-70Hz frequency range of the magnetic source signal, then using SAM analysis to locate epileptogenic focus of the children with absence epilepsy.ResultsThere were five cases in thirteen cases of childhood absence epilepsy were found epileptogenic focus, they were all localized in the bilateral frontal lobe. Conclusion Part of children with absence epilepsy had the epileptogenic focus, and part of childhood absence epilepsy may serve frontal lobe as the region of epileptogenic focus, MEG detection combined with SAM analysis may have certain diagnosis value in the localization of epileptogenic focus of childhood absence epilepsy.