The Mechanisms Of Modulation Of SNSR On Morphine Tolerance

Sensory neuron-specific receptor (SNSR) is uniquely located in the small diameter neurons in dorsal root ganglia (DRG) and trigeminal ganglia (TG), that them may be related with nociceptive processing.The present study was designed to investigate the effect of SNSR on morphine tolerance and its possible cellular mechanisms using Western blot techniques. The results showed that:continuous injection of morphine 6 days produced an increase in the expression of protein kinase C(PKC) and nruronal nitric oxide synthase(NOS), but TRPV1 is not changed in the dorsal root ganglia and DRG; Intermittent co-administration of bovine adrenal medulla 8-22 (BAM8-22) with morphine could inhibit the production of morphine tolerance, prevented the morphine-induced increase in PKC and nNOS but the expression of TRPV1 unchanged.This study shows that activation of SNSR can inhibit morphine tolerance and its mechanism may be related to PKC and NO signaling pathways, but if related to TRPV1 signaling pathway has to research more.