The Application And Value Of Measuring Serum Tumor Markers In Diagnosis And Cure Of Gastric Carcinoma

Objective: ROC curve was used to analyze the results about peripheral bloodCarcinoembryonic Antigen(CEA),Cancer Antigen 72-4(CA72-4),Carbohydrate Antigen199(CA199),Cancer Antigen 125(CA125) from 235 patients with gastric carcinoma,110control group,and discover how to use 4 kinds of TM serum standard to diagnose gastriccancer.With the help of relations to the pathology and TNM staging of gastric cancerpatients,analyze the impact factors of 4 serum TM standard and discover their applications infuture cure of gastric cancer and predicting prognosis.Methods: Measure the peripheral blood Carcinoembryonic Antigen(CEA),CancerAntigen 72-4(CA72-4),Carbohydrate Antigen 199,Cancer Antigen 125 standard of 235cases in gastric cancer group and 110 cases control group to investigate the diagnostic valuein gastric carcinoma. First,to discuss how to use tumor markers properly in gastricdiagnosis,we contrast the sensitivity,the specificity and availability of single and combinedtumor makersï¼›To evaluate the value of serum tumor markers standard in gastric cancerdiagnosis through ROC curve.Secondly,we discuss the relationship between the tumormarkers and the pathologic types,the tumor-node-metastasis(TNM) staging et al . todiscuss the application of TM in the cure of gastric carcinoma and predicting prognosisaccording to analyze the impact factors on TM standard.Statistics: Use SAS 9.0 to analyze the data.The adopted statistics algorithms are ROCcurves,non-parametric rank sum test and correlation analysis.Results:(1)CA72-4 has the highest sensitivity with 34.47%,and CA72-4> CEA >CA199 >CA125.When it comes to the combination,CEA+CA72-4 is the highest with53.62%,and CA72-4+CA199+CA72-4 with 58.30%,CA72-4+CA199+CA72-4+ CA125with 97.3% but has the lower specificiry.(2)The sex,age and the serum levels of CA72-4,CEA and CA125 had a significant difference between the gastric carcinoma group and thecontrol group(P<0.05),there was no significant difference with the CA199.(3)ROC curveshowed that the under-curve area(AUC)of CEA,CA72-4,CA199 and CA125 were: 0.657,0.663,0.604 and 0.570 respectively.The under-curve area of CA72-4 was the largest while the area of CA125 was the minimum.According to ROC curve analysis,the clinicaldiagnostic critical points of CEA,CA72-4,CA199 and CA125 in patients with gastriccarcinoma were 3.37ng/ml,3.465U/ml,14.525U/ml,25.67U/ml(. 4)CEA has a relationshipwith the pathologic type while others are meaningless.(5)CA72-4 as relations to themetastasis extent of lymph node(N)ï¼›Besides,CEA also has relations to the vas metastasis.Conclusion: (1) The way of using only CA72-4 has the highest sensitivity with34.47%.When it comes to the combination,CA72-4+CA199+CA72-4 is the best ,the next isCEA+CA72-4.(2)CEA has a relationship with the pathologic type while others aremeaningless.(3) CA72-4 as relations to the metastasis extent of lymph node(N)ï¼›Besides,CEA also has relations to the vas metastasis.