| Objective:To investigate the features and clinical implications of event relatedpotential(ERP) and cognitive-processing in patients with depression, anxiety or both anxiety and depression.Methods:A total of 85 patients with anxiety,188patients with depression, 35 Patients with both anxiety and depression, and 70 health volunteers were recruited in the study. The event related potential 1 were recorded by Nihon Kohden instruments.Results:P300:Compared with the healthy volunteers, the latency of P3a and P3b or N2 was longer (P<0.05)and the amplitude of N1 and N2 or N2-P3b was lower in the patients with anxiety or depression (P<0.05), and the amplitude of P2 is higher(P<0.05); the latency of N2 and P3a or P3b was longer and the amplitude of N1 and N2 was lower (P<0.05) in the patients with both anxiety and depression. The latencies of P3a and P3b in the patients with anxiety and both anxiety and depression were longer than in the patients with depression(P<0.05). The amplitude of N2-P3b in the patients with anxiety and depression was higher than in the patients with anxiety or depression(P<0.05) and the P2 is on the contrary(P<0.05). The Amplitude of P2 in the patients with anxiety was higher (P<0.05) in the patients with anxiety and depression; MMN:The amplitude of four groups was constanly. The latencies of anxiety and depression was longer than the other groups(P<0.05); CNV:Compared with the healthy volunteers, the latencies of A was longer and the amplitude of A-B is lower or the areas of A- S2' and S2'-C was shorter in the depression(P<0.05).. The amplitude of A-B is lower and the areas of A-S2'was shorter in the anxiety(P<0.05).. The latencies of C was longer and the amplitude of A-B is lower or the areas of S2'-C was shorter in the anxiety and depression(P<0.05).. The latencies of A was longer and the areas of A-S2'in the depression was shorter than the anxiety(P<0.05).. The latencies of C of the anxiety and depression was longer than the depression(P<0.05).; P50: Compared with the healthy volunteers, the P50 was higher than the patients with anxiety and depression or both anxiety and depression (P<0.05).Conclusion:The features of ERP in patients with depression are different from those with anxiety, which provides an electroneuro -physiology basis for the clinical diagnosis and differential diagnosis for anxiety and depression. |
