Study Of Diffusion Tensor Imaging And Proton-related Spectral In Intracranial Tumor

Objective:To evaluate the value of diffusion tensor imaging by measuring the FA values, the ADC values and DTT Techniques in diagnosis of intracranial tumors(different-grade, neurogliocytoma, meningoma, metastases)and infiltration of high-grade glioma. Materials and Methods:Sixty-three patients with intracranial tumors, including twenty high-grade gliomas, fifteen low-grade gliomas, sixteen meningomas and twelve metastases, were underwent respectively by conventional MR and diffusion tensor MR imaging.(1) FA values and ADC values were measured in the parenchyma of tumor, edema of tumor, normal-appearing white matter adjacent to the tumors and contralateral normal white matter. The value levels were compared among those areas for the same or different tumors, then did interclass statistic analysis.(2) The brain white matter fibers of different area such as the parenchyma of tumor, edema of tumor, normal-appearing white matter adjacent to the tumors and contralateral normal white matter were rebuild by the data of DTI. The valuable information was provided for the diagnosis and differential Diagnosis of intracranial tumors by observing the change of DTT.Results:1 The Comparison of ADC values(1)The ADC values to change from high to low in different area of high-grade glioma, lower-grade glioma, Meningoma, metastases were edma area, parenchyma of tumor, normal-appearing white matter adjacent to the tumors. These numerus in high-grade glioma were 1.47±0.045×10^-9mm²/s, 1.23±0.018×10^-9mm²/s, 0.86±0.023×10^-9mm²/s. These numerus in lower-grade glioma were 1.72±0.061×10^-9mm²/s, 1.44±0.058×10^-9mm²/s, 0.93±0.012×10^-9mm²/s. These numerus in Meningom were 1.719±0.039×10^-9mm²/s, 0.91±0.065×10^-9mm²/s, 0.78±0.013×10^-9mm²/s. These numerus in metastases were 1.65±0.039×10^-9mm²/s, 1.24±0.045×10^-9mm²/s, 0.82±0.026×10^-9mm²/s.(2)Significant differences of ADC values were found in parenchyma of tumor and edma area compared with contralateral normal white matter in different-grade neurogliocytoma, meningoma and metastases(P<0.01).The ADC values of parenchyma and edma area of tumor were higher than the contralateral normal white matter, showed significant differences between them(P<0.01),while there were no significant differences between normal-appearing white matter adjacent to the tumors and the contralateral normal white matter.(3)The parenchyma ADC values of high-grade glioma, lower-grade glioma, meningoma and metastases were lower than the edema area, showed significant differences between them(P<0.05).(4)Among the four different intracranial tumors, meningiomas had the lowest ADC values in parenchyma area. There were statistical significance between Meningoma and metastases as well as different-grade neurogliocytoma(P<0.05);The parenchyma area ADC values have statistical significance between high-grade glioma and lower-grade glioma(P=0.005). Among the four different intracranial tumors, high-grade glioma had the lowest ADC values in edema area.There were statistical significance between high-grade glioma and lower-grade glioma(P<0.05).(5)Among different intracranial tumors,the FA values to change from high to low in parenchyma area were Meningoma, high-grade glioma, lower-grade glioma and metastases, These numerus were 0.23±0.02, 0.19±0.02,0.14±0.013,0.13±0.004.In edma area of different tumors, high-grade glioma had the lowest FA values 0.141±0.006, subsequently one by one were lower-grade glioma, Meningoma and metastases. These numerus were 0.17±0.013,0.18±0.011,0.187±0.017.2 The Comparison of FA values(1)The FA values of parenchyma area and edma area were obviously lower than normal-appearing white matter adjacent to the tumors as well as contralateral normal white matter, showed significant differences between them(P<0.001).There were no statistical significance between parenchyma area and edma area in the same tumor(P>0.05).(2)The parenchyma area FA values of high-grade glioma were higher than lower-grade glioma, showed significant differences between them(P=0.025). High-grade glioma had the lowest FA values in edma area, the FA values were different statistically compared with high-grade gliomas and lower-grade gliomas, meningoma, metastases(P<0.05), while the last three have no differences between each other(P>0.05).(3)Only high-grade gliomas had this kind phenomenon ,FA values of normal-appearing white matter adjacent to the tumors were lower than contralateral normal white matter, and there were significant differences between them(P=0.011).3 The change of white matter fibersThe white matter fibers major change of high-grade gliomas and metastases were destruction and infiltration; The white matter fibers major change of lower-grade gliomas and meningoma were justle and shifting.Conclusions:(1) ADC values can be used to differentiate parenchyma of tumor, edema region, normal-appearing white matter adjacent to the tumors and contralateral normal white matter.(2)FA values add no benefit to tissue differentiation.ADC and FA values can be helpful for the differential diagnosis of intracranial tumor, also can be used to classify diagnosis for glioma.FA value is helpful in detecting tumor invasion.(3) The valuable information were provided for the diagnosis of innate and maligant tumor. by observing the change of DTT. Objective:To evaluate the value of multi-voxel magnetic resonance spectroscopy in the peritumoral areas of glioblastoma.Materials and Methods:Fifteen patients with glioblastoma were underwent conventional MR, proton-related Spectral MR imaging and contrast-enhanced structural before therapy. The ratios of Ch/Cr, Ch/NAA,NAA/Cr were measured in edema region and normal-appearing white matter adjacent to the tumors, and the ratio of NAA/nCr were computed in normal-appearing white matter adjacent to the tumors. The value levels were compared with contralateral normal white matter, then did interclass statistic analysis.Results:(1)The ratios of Ch/Cr, Ch/NAA, NAA/Cr in edema region were1.83±0.31, 1.25±0.254, 1.32±0.149; The ratios of Ch/Cr, Ch/NAA, NAA/Cr in normal-appearing white matter adjacent to the tumors were 1.43±0.225, 1.28±0.248, 1.37±0.535, 1.19±0.168; The ratios of Ch/Cr, Ch/NAA, NAA/Cr in contralateral normal white matter were 1.16±0.109, 0.70±0.181, 1.73±0.295, 1.82±0.554.(2)The ratios of Ch/Cr, Ch/NAA in edema region and normal-appearing white matter adjacent to the tumors were higher than contralateral normal white matter, and there were significant differences between them(P<0.05).(3)The ratios of NAA/Cr in edema region were lower than contralateral normal white matter, showed significant differences between them(P<0.05). The ratios of NAA/Cr in normal-appearing white matter adjacent to the tumors were lower than contralateral normal white matter, but there were no significant differences between them(P=0.177), and in corresponding area, the ratios of NAA/nCr were lower than contralateral normal white matter, showed significant differences between them(P=0.023).Conclusions:The application of multi-voxel magnetic resonance spectroscopy and the measurement of metabolite ratios can be helpful for concluding brain invasion in the normal-appearing white matter adjacent to glioblastoma.