Skin Needle Joint Drug On Experimental Study Of Capillary Function Comb

OBJECTIVES to explore skin needle joint drug therapy in the treatment of superficial part role of vascular anomalies provide theoretical basis for clinical treatment.METHODS Choose a male chicken, random 50 divided into 5 groups, each group of 10 only. As with cockscomb, using animal models of skin needle combined different drug combination treatment cockscomb ,according to the drug division pingyangmycin, triamcinolone acetonide, with pingyangmycin triamcinolone acetonide joint, physiological saline needle treatment group, which in turn for A, B, C, D four the experimental group, normal without any processing comb as control group E, respectively in treatment of 1d, 14d, 21d 7d, 28d dynamic observation, the gross and comb organization pathological changes (HE dyed + Massons dyeing), capillary number and apoptosis index changes. Meanwhile testing blood biochemical, and observed the lung tissue pathology change.RESULTS With the extension of observation period, each group cockscomb in different degree color becomes lighter becomes weak, mirror dermal observed under normal group which is reduced capillary (P﹤0.05), present slow down trend, which most obvious reduction group C, D group reflect the lightest; Capillary interval collagen fiber hyperplasia, among them the most obvious; A group of proliferation Each group apoptosis index, besides group B (needle﹢triamcinolone acetonide) and D group (needle﹢saline) changes slowly, basic no obvious change (P﹥0.05) outside, coupled pingyangmycin group (group A and C group) apoptosis increase gradually, among them with index of group A (needle﹢pingyangmycin) apoptosis, the most obvious response. 4 weeks, animal blood biochemical tests and lung tissue pathology results showed no differences are more normal (P﹥0.05).CONCLUSION Skin needle roller grinding mechanism and drug interactions all can effectively reduce the number of comb organization, and both capillary action can accumulate, which coupled pingyangmycin best effect. This way for systemic adverse reaction of small.