Therapeutic Effect Of Mixture Of Salvia Miltiorrhiza And Rhubarb On Severe Acute Pancreatitis (SAP) Intestinal Endotoxemia In Rats.

Severe acute pancreatitis(SAP) intestinal endotoxemia rats.Discuss the mechanism of Mixture of Salvia miltiorrhiza and Rhubarb on Severe acute pancreatitis(SAP) intestinal endotoxemia rats Methods: Devide 30 Wistar rats into 3 groups named Controlgroup(SO) and Model group andTheraphy group randomly and equally,set Model group and Threapy group as SAP model, intervene Theraphy group with Mixture of Salvia miltiorrhiza and Rhubarb,detect every group,s TNF-α(tumor necrosis factor-α),ET(endotoxin),DAO(diamine oxidase) in blood 12 hours later in ELISA, And observe degree pathological changes of Intestinal mucosa in hematoxylin-eosin staining.Result: 1: 12h afterb inject operation, rats pancreas severely congested edema.2: TNF alpha, ET, DAO of Model rats is obviously rise.3: Threapy group's TNF alpha, ET, DAO is lower than Model group.Conclusion:1: sodium taurocholate backward injection in Bile duct is capable to set Severe acute pancreatitis model.2: Severe acute pancreatitis can leads to Intestinal Endotoxemia3: Mixture of Salvia miltiorrhiza and Rhubarb can ease Intestinal Endotoxemia caused by Severe acute pancreatitis...