H1N1 Virus Analysis Of The Evolution Based On Structure

Evolutionary Bioinformatics analysis of the important areas of research is determined according to characteristics or genes from the data, the Origin of Species, and a relationship, we analyze the results of the phylogenetic tree is usually in the form of visually presented. Phylogenetic tree and evolutionary branch from the nodes, each node represents a taxonomic unit, evolutionary branch taxa defined the relationship between the branches of evolutionary tree topology of the image is called evolution, which indicates that the branch length and branch evolution the extent of the change, marked the evolution of the branch called the branch length scale branches. Currently most used phylogenetic tree was constructed in three ways:distance, maximum parsimony, maximum likelihood method. From the sequence similarity, the maximum parsimony method for the case of very high sequence similarity, distance method has high similarity in the sequence when applicable, the maximum likelihood method can be used for any collection of related sequences, so the sequences selected when no similar maximum likelihood method is more appropriate. View from the computing speed, distance method the fastest, followed by maximum parsimony, maximum likelihood method the most time-consuming.H1N1 subtype influenza A viruses (denoted as A (H1N1) or H1N1), influenza A virus is a kind of human influenza virus infection in one of the most common. The spread of the H1N1 virus is faster and has a high variability, a continuous emergence of new strains, new subtype, and even new species, so that humanity faces the problem of anti-virus is more severe.Phylogenetic analysis and evolutionary trees Bioinformatics Building work is an important field of research, according to the topology of the phylogenetic tree of the virus can be evolutionary relationship between the molecules; through the evolutionary tree of the branch length estimate can be approximated by calculating also the differentiation of taxa time.Currently, phylogenetic tree building were carried out based on the sequence, but have found very different in many RNA primary sequence, molecular sequence alignment by the result of evolution is not satisfactory, the study found the conserved sequence of RNA structure, a more than, RNA sequence evolution may change, but its folding patterns more conservative, even seventy percent of the sequence changes, it would not be large folding patterns to change this structure is that you can get more than the sequence comparison more accurate and more structural information. Comparison of the molecular structure of RNA and RNA primary sequence comparison, compared with more advantages.In this paper, influenza A H1N1 influenza virus HA gene fragment as the research object, the first point of the structure-including the conversion applied to the phylogenetic analysis, the match the sequence of secondary structure into a new sequence patterns, and the Phylip software application Clustalw2 for comparison and phylogenetic tree was constructed to analyze the results, get the results. Then obtained with the phylogenetic tree based on sequence comparison, then the results of HA fragments with viral sequences were compared Barcode bar code, get more accurate results. Phylogenetic tree using query, analysis, processing of information benefits are clear. Analyze problems, we can "information field" pre-marking, and enhance the correlation between the information already. Evolutionary tree to show the intuitive and objective information to facilitate easier for people to analyze information. According to the book about the professional approach, people in the analysis phase to the branches of the phylogenetic tree can be filled with good. With the structural analogy, and other innovative methods, evolutionary tree can help us get new ideas and technology solutions. This is likely to have influenza virus evolution research play reference research.