Analysis Of Blood Flow In Type B Aortic Dissection By Numerical Simulation

Cardiovascular diseases have been the serious threat to human life for the past few years. Among all the diseases, Type B thoracic aortic dissection (TBAD) may lead to rupture of vessels and thus death of the patient. It can also causes distal vital organs severe ischemia due to the formation of the false lumen. Although the emergence of endovascular graft exclusion of surgical treatment for aortic dissection has brought the revolutionary change, there are still many undecided factors.The occurrence and development of TBAD is intimately related to the high-speed and high-pressure blood flow pulsation in aorta.The research of hemodynamic changes after TBAD and blood dynamics in aorta after endovascular graft exclusion has important meaning to clinical prevention of TBAD. Using the hot topic of hemodynamic research advantage,the numerical simulation of blood flow in TBAD is studied by Using fluid mechanics method in this thesis. The blood flow field and the physiological change rule of vascular wall lesions, and after surgery in TBAD are also studied.In this study, three research model including normal heart aorta,TBAD and postopration TBAD have been reduced to different type of bending pipes with clapboard and duct.The corresponding flow models are also built. During fluid mechanics calculation process, the heart pulse wave function is used as inlet velocity by UDF function and the blood is used as flow media. The distribution of velocity,path line,wall stress and wall shear stress of different bending pipes in different time were obtained. Blood flow in post-surgical configuration of such TBAD patients was simulated by Computational Fluid Dynamics techniques in these pipes.These results can reflect the relationship between the occurrence, development and postoperative healing of TBAD and the hemodynamic .These findings not only provide theoretical basis for TBAD pathogenesis but also form parameters testing and analysis method for blood flow in TBAD.The simulations will be highly relevant for clinical practitioners in determining the methods of treatment.This topic does a multidisciplinary integrated research on TBAD, is closely related to the biofluid dynamics, medical and computational fluid mechanics etc, It makes up the deficiencies of pure biochemical research can reflect the TBAD pathogenesis and development rule comprehensively. It is of great significance in both scientific research work and realistic application.