Influence Of Plasma Tumor Necrosis Factor α(TNF-α) In The Peripheral Blood And Thrombi Function Items Of Acutely Exacerbated Chronic Obstructive Pulmonary Disease (AECOPD) With Modified Weijing Decoction

Objective:Observe the clinical effect of AECOPD patients (phlegm and heat syndrome in the lung in TCM)with modified Weijing decoction, and observe influence on the level of TNF-a, D-dimer and thrombi function items. Observe whether there is a prethrombotic state(PTS) in patients with AECOPD; discuss the relation between inflammation and PTS; sum up to the theory of intermingled phlegm and blood stasis; comprehend the PTS in patients with AECOPD by the theory of interrelation between phlegm and blood stasis, observe if modified Weijing decoction can raise the clinical effect of AECOPD patients by improve PTS, provide the clinical and theory foundation by the theory of interrelation between phlegm and blood stasis.Method:60 AECOPD patients of phlegm and heat syndrome in the lung in TCM randomly divide into two groups. All the patients receive a regular treatment with western medicine. The patients in trail group had an additional treatment with Modified Weijing Decoction in 7 days a course of treatment. On the end of the course made a contrast between the trail group and control group on clinical effect and obverted the change before and after the treatment on clinical symptom,blood gas analysis,blood routine,TNF-αand bleeding and clotting tests. Through SPSS13.0 to make an analysis.Results:1. The integral of symptoms and signs of the trail group were significantly higher than the control's. The total effective rate of the trail group was 93.33%, precede the control's 86.67%.2. The patient's index of TNF-α,D-dimer FIB and APTT rose significantly before treatment and declined in varying degrees after treatment (P<0.05). The trail group had a more obvious improvement than the control group on TNF-a, D-dimer FIB and APTT(P<0.05). But there were indifference with PT and TT before treatment in the two group(P>0.05), also there were indifference after treatment.3. TNF-αand D-dimer had a positive correction(r=0.38, P<0.05).Conclusion:1. The treatment with Modified Weijing Decoction base on the theory of intermingled phlegm and blood stasis for patients with phlegm and heat syndrome in the lung in TCM AECOPD could significant improve the symptoms and signs, could had preferable therapeutic effect by the theory of intermingled phlegm and blood stasis with AECOPD (phlegm and heat syndrome in the lung in TCM).2. Modified Weijing Decoction could relieve inflammatory by reduce TNF-a,thereby develop it's therapeutical effect.3. Patients with AECOPD had a state of PTS, Modified Weijing Decoction could improve PTS in Patients with AECOPD, and it would be the reason of Modified Weijing Decoction could improve therapeutic effect with AECOPD (phlegm and heat syndrome in the lung in TCM).4. The D-dimer elevated significantly in the Patients with AECOPD. The elevated level of them had a relation with the elevated level of TNF-α, which referred that inflammation related to PTS.