| Objective: As hospitalized patients with different skin lesions and diseases, and the resulting anti-infection treatment on different principles, these may lead to the bacterial composition, distribution, pathogenicity and drug resistance of the pathogen in dermatology ward differing from other general wards. Identifying these differences is an important guidance for the proper use of antibiotics to effectively treat patients with dermatological infections. In this study the bacterial cultueres hospitalized patients in department of dermatology in the Second Hospital of Hebei Medical University were reviewed from July.1st,2009 to July 1st,2010.We retrospectively analyzed the susceptibility tests of bacterial culture, the kind of diseases in hospitalized patients, bacteria and drug susceptibility results. Our study was to get a preliminary understanding of inpatient with skin disease on rank of strain, drug sensitivity and distribution of disease.Methods: 544 inpatients'records in the department of dermatology of The Second Hospital of Hebei Medical University from July.1st, 2009 to July 1st, 2010 were reviewed. The data of bacterial culture among those patients was analyzed. The points focused on strain,drug sensitivity and the skin diseases associatited with the positive samples.Results:1 Results: 102 patients out of 544 in hospitalized patients were carried out bacterial culture during July.1st, 2009 to July 1st, 2010 in department of dermatology of The Second Hospital of Hebei Medical University. The percentage of hospitalized patients performed bacterial culture was 18.75 % (102/544); The percentage of patients having positive results out of the total hospitalized patients was 11.03% (60/544); 198 times of bacterial culture sensitivity tests were finished (the same results were not taken down repeatedly the same patient ). The percentage of of positive times out of 198 was 55.56% (110/198), while the percentage of negative times accounted for 44.44%2 Of the total positive results, Gram-positive coccus accounted for 64.55% (71/110). Staphylococcus aureus accounted for 49.30% (35/71), which was the largest share, followed by coagulase-negative staphylococcus, the proportion was 33.80% (24/71). Of the total positive results, Gram- negative bacteria accounted for 35.45% (39/110).3 Among the total positive results, the top rank of four strains of bacteria on quantity in order was Staphylococcus aureus, coagulase-negative staphylococcus, Klebsiella pneumoniae, Escherichia coli. The drug-resistant rates of Staphylococcus aureus and coagulase-negative staphylococcus to linezolid, teicoplaninn and vancomycin were zero, while to penicillin G and erythromycin were 91.42% and 77.14%.The drug-resistants rates of coagulase-negative staphylococcus to erythromycin, penicillin G and cefoxitin were 100%, 91.67%, 87.5%.To imipenem, ciprofloxacin, cotrimoxazole for Klebsiella pneumoniae were zero, 66.67% and 66.67%; To imipenem, meropenem and amikacin, for Escherichia coli cefotaxime, were zero; To cefotaxim cefuroxime and ciprofloxacin, were 100%, 88.89% and 88.89%.4 38strains of methicillin-resistant Staphylococcus(MRS) were found, including 13 strains of methicillin-resistant Staphylococcus aureus, 25 strains of coagulase-negative Staphylococcus aureus. The percentages of methicillin resistant staphylococcus aureus (MRSA) and methicillin resistant coagulase- negative Staphylococcus aureus (MRSCN) were 37.14% and 87.5%, respectively. 20 strains of extended spectrumβ-lactamases (ESBLs) were found, including 9 strains of Escherichia coli and 9 strains of Klebsiella pneumoniae.Conclusion:1 The antibiotic resistance of bacterial culture in department of dermatological ward was very serious. The monitoring on the changes in antibiotic resistance should be carried out regularly, and the administration of antibiotic should be based on susceptibility test results rationally.2 Because of the nature and characteristics of skin diseases, of the total positive results, Gram-positive coccus was predominant, and secretion was the largest share in all samples for inspection.3 Methicillin-resistant Staphylococcus aureus were multiple-antibiotic- resistant,including penicillin G,erythromycin,cefoxitin and clindamycin.The resistance rates for them were greater than 80%;while the resistance rates for linezolid,teicoplanin,vancomycin were very low.The resistant rates of Extended spectrumβ-lactamase (ESBL) strains to 16 antibiotics than imipenem, meropenem were significantly higher than no-ESBL producing strains. The resistant rates of Extended spectrumβ-lactamase (ESBL) strains to imipenem and meropenem were zero. It suggests that the treatment to infections caused by ESBLs-positive bacteria,should be preferred to imipenem, meropenem or other carbapenems antibiotics. |
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