A Study Of The Correlation Between The Level Of Serum Ferritin And Pre-diabetes Stage

Background : In recent years, the level of serum ferritin (SF) was considered the vital independent predictor in the occurrence and development of diabetes , and it becomes a hotspot in research. Whether it also exists the obvious change of SF levels in pre-diabetes stage?Objective This study investigates the level of serum ferritin in pre-diabetes stage, and analyzes the correlations of them, speculates the mechanisms in it.Maybe it can help us to detect and prevent the disorders in glycometabolism earlier.Methods: The research objects were come from Anhui Provincial Hospital cadres ward from November 2009 to April 2010, excluding diabetes and hemoglobin concentrations below 12 mg/dl and those with acute or chronic infectious disease, malignant tumors etc, and taking the drugs which can interfere glycometabolism and ironmetabolism. By OGTT test, a total of 106 objects were divided into two groups according to the fasting glucose, Group A : Pre-diabetes Group (i.e. Impaired Fasting Glucose IFG Group), with fasting glucose (FPG)≥6.1mmol/L (110mg/ml), and <7.0mmol/L ( 126mg/ml) ; Group B: Control Group with fasting glucose<5.6 mmol/L (100 mg/ml) ,OGTT2h<7.8mmol/L ( 140mg/ml). Compare the two groups of risk indicators such as age, sex, body mass index, smoking history, blood pressure, cholesterol, triglyceride , ferritin, c-reactive protein, white blood count and carry out correlation analysis.Results: (1) Group A (Pre-diabetes Group) the level of serum ferritin is obviously higher than group B( Control Group), (118±12μg / L vs. 62±5.9μg / L, p < 0.001); (2) A positive correlation was found between fasting glucose and serum ferritin (r = 0.30,p < 0.001);. (3)The odds ratio for the association of Group A in male subjects with a high serum ferritin level than females ; (4)Using multiple regression analysis, we found an association between serum ferritin and fasting glucose (r =0.30,p < 0.001) , blood pressure(r =0.16,p < 0.01), triglyceride(r =0.09,p < 0.01) and cholesterol (r =0.07,p < 0.05). but it is no obvious association with BMI (r =0.06,p > 0.05)。Conclusions: (1) Before overt diabetes, we can see the level of serum ferritin is obviously elevated in pre-diabetes stage, and a positive correlation was found between them, which suggesting the serum ferritin is a risk factors of the disorders in glycometabolism. (2)In pre-diabetes stage, to reduce intakeing iron by dietary and iron storage of body, may be effective prevention of diabetes. (3) Actively detect the level of serum ferritin in clinic, may help us finding potential patients with diabetes.If we take appropriate interventions, it may be prevent the occurrence of diabetes and bring some great social benefits.