| Objective:To explore the distribution and the main factors of blood pressure, and investigate the effect of clustering of cardiovascular risk factors on high-normal blood pressure in pre-conception women.Methods:With the cluster sampling, we randomly chosen 6 towns from Liuyang rural areas and recruited voluntary participants who plan to pregnancy in pre-marriage clinics. All kinds of information were collected by questionnaire, physical examination and blood sample after signing the informed consent. We also used the F test andχ2 test for the single-factor analysis, and used the multiple linear regression, unconditional logistic regression and classification and regression tree for the multi-factor analysis.Results:1.912 pre-conception women were investigated in our study. The mean of SBP was 109.57±13.55mmHg and the mean of DBP was 70.54±9.17mmHg.The prevalence of hypertensive was 1.75% while the prevalence of high-normal blood pressure was 31.14%.2. Multiple linear regression analysis showed that the correlation coefficient between SBP and Per capita household income, WC, Hcy, LDL-C, HDL-C, the women Engaging in commercial and service were 4.096,0.276,0.287,2.396,-3.492 and-6.453. The correlation coefficient between DBP and per capita monthly income in family, WC, Glu, Hcy, LDL-C, HDL-C, the women Engaging in commercial and service was 2.657,0.175,0.677,0.213,1.151,-2.311 and-3.163.3. Multinomial Logistic regression analysis showed that education level (OR= 2.063 in high school and junior middle school group, OR= 2.228 in elementary school or lower education level group),per capita monthly income in family (OR= 2.743 in 1000～group, OR=3.478 in 2000～group), waist circumference (OR= 1.776 in P25～group, OR= 2.064 in P50～group, OR= 2.364 in P75～group), glucose(OR= 1.998 in P75～group), triglyceride (OR= 1.315 in P75～group), total cholesterin (OR= 1.412 in P75～group) were associated with high-normal blood pressure.4. After adjustment for age, high-normal blood pressure were associated with mutually clustering of cardiovascular disease(CVD) risk factors (χ2=20.904 P=0.000).High-normal blood pressure incidence rate increased significantly with the number of CVD risk factor clustering in individuals. Odds ratio (OR) of high-normal blood pressure which risk factors score was 1,2 and≥3 was 1.417(1.024-2.091),2.26(1.409-3.853) and 3.099(1.683-6.785), respectively. In the normal group, if control the cluster of any two cardiovascular risk factors, the normal-high blood pressure incidence will be reduced 9.37%.5. Classification tree analysis showed that abdominal obesity, high-TG, high-Glu, high-TC were risk factors of high-normal blood pressure. A positive interaction between abdominal obesity and high-TG was also showed.Conclusion:1. The prevalence of high-normal blood pressure in pre-pregnancy women was 31.14%, which was higher than the national level of female.2. SBP and DBP were positively correlated with per capita monthly income in family, WC, Hcy, LDL-C, and women engaging in commercial and service were lower than the housewife. In addition HDL-C was negatively correlated with SBP and Glu was positively correlated with DBP. 3. The higher per capita monthly income in family and WC,Glu, TC, TG and Hcy in the highest quartile will increase the risk of high-normal blood pressure in the pregnant women.4. The prevalence rate of high-normal blood pressure increased with clustering of CVD and pre-pregnancy women clustering two CVD risk factors was the key population of blood pressure prevention.5. Abdominal obesity and high-triglyceride can be as predictors of high-normal blood pressure.
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