Analysis Of The Status And Risk Factors Of Drug Resistant Tuberculosis In The City Of KaShi In XinJiang

Objective:study the status of the drug resistence of mycobacterium tuberculosis, discuss factor influencing drug resistence to mycobacterium tuberculosis in the city of kashi, xinjiang province, and provide theoretical evidence for tuberculosis control and prevent strategy in the future. Methods:136 sputum specimens of smear positive, were collect from all in-patient cases of tuberculosis from June to December 2010 in KaShi Chest Hospital, Ameliorative Lowenstein-Jensen culture medium was used to detect bacillus, positive specimen o f pulmonary tuberculosis by typing using PNB and TCH. To tally 136 samples were confirmed to be positive by culturing. Drug susceptibility test against streptomycin(INH, SM, RFP, EB, OFX, Km, Amk, Cm), was conducted by the proportion method, and collect the chinical data by retrospective method.Results:Among 136 sputum specimens containing Mycobacterium tuberculosis,109 strains (8015%)were identified to human pulmonary tuberculosis; 26 strains (19.12%) were identified to bovine pulmonary tuberculosis; strain(0.74%) non-tuberculosis mycobacteria.56 were from patients of primary tuberculosis, while 80 from patients of recurrent tuberculosis.the rate of total drug resistance was32.35%, the rate of initial drug resistance was28.57%, the rate of acquired drug resistance was35.00%, the rate of total multidrug resistance was6.62%, the rate of initial drug multidrug resistance was3.57%, and the rate of acquired drug multidrug resistance was8.75%, and no XDR-TB was found in this study. Any resistancetoINH, SM, RFP, EMB, OFX, Cm, Km, Amkwas22.79%,11.76%,8.82%, 6.62%,2.94%,2.94%,0.74%,0.74%, Respectively. In the former group, the rate of drug resistance to eight anti-tuberculosis medications including INH, SM, FPR, EB, OFX, CPM, K and AK was 17.86%,16.07%,3.57%,5.36%,3.57%,0%,0%,0%; in the latter group, the rate of resistance to eight anti-tuberculosis drug was 26.25%,8.75%,12.50%, 7.50%,2.50%,1.25%,1.25%. The resistant rates to 1,2,3 and 4 or more drugs were 17.86%,3.57%,5.36%and0% in new cases and 5.00%,13.75%,3.75% and 0% in previously treated cases, comparing patients from primary versus recurrent evaluated by X2 test, there was a statistically significant difference in the resistant rates to 2. The total drug resistant rate did not show significant difference (P>0.05) among different age groups; The initial drug resistant rate did not show significant difference (P>0.05) among different sex and age groups. Single non-conditional logistic regression analysis showed that The differences of gender,culture level,live address,occupation,chronic disease,cavity,the history of previous treatment,delaye were not significantly correlated with drug resistance(P>0.05). Conclusion:To study, The rate of man-Mycobacterium tuberculosis was higher than that to other Bacteriums. The incidence of TB drug resistance is high and merit s at tention in the city of KaShi in Xin Jiang province. The problem of drug resistance was noted in 8 anti-tuberculosis medications to various degrees.This study demonstrated that the top three highly-resisted drug were isoniazid,streptomycin and rifampin.The initial drug resistant rate did not show influence among different sex and age groups. Routine Mycobacterium tuberculosis culture and drug susceptibility test were helpful in selecting anti-tuberculosis drug in a scientific,reasonable and effective manner.such tests also had epidemiological significance for controlling spread of tuberculosis.