| Objective:To investigate the effect of A.membranceus injection for hemopoietic and immune function reconstruction in children with acute leukemia after chemotherapy. Methods:Sixty-three leukemia children at remission inducing stage of initial treatment were randomly assigned to two groups,the reatment group treated with A.membranceus (0.5～1ml/kg/daily)plus chenmotherapy and the contorl group only treated with chemotherapy for 35 days,with same supportive treatments administered to both.Levels of blood routine test,T lymphocyte subsets(CD3+ CD4+,CD8+,CD4+/CD8+)and NK cell were detemined before and after treatment, and the remission rate was assessed after treatment.Results:The remission rates in the two groups showed no significant difference[84%(26/31) vs 75%(24/32),(P>0.05)] statistically.Levels of peripheral leucocyte count and hemoglobin as well as levels of CD3+,CD4+/CD8+ were significantly higher in the treatment group than in the control group (P<0.05),but no significant difference was shown between groups in CD4+,CD8+,NK cell level. Conclusion:A.membranceus can lighten the inhibition of chemotherapy on hemopoietic function of pone marrow and promote its recovery,enhance the immune function, Moreover the patients of the A.membranceus treated group suffered fewer infections which could be controlled more easily also with decreased administration days of antibioticse and improve the quality of life in atients with acute leukemia undergoing chemotherapy.
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