The Research On Chaishao Liujunzi Decoction With Sweet And Bland Dampclearing Herbal Medicine Against Lier Constraint And Insufficiency Of The Spleen Of Chronic HBV Patient

This essay aims to discuss the clinical effects of Chaishao Liujunzi Decoction with Sweet and bland Dampclearing Herbal Medicine on the basis of the theory on lier constraint and insufficiency of the spleen of chronic HBV patient with hidden dampness.Method:95 lier constraint and insufficiency of the spleen of chronic HBV patients were recruited. They were classified into 3 groups, including the first group is Conventional Treatment Group with 31 subjects, the second group of Chaishao Liujunzi Decoction with 32 subjects and the third group of Chaishao Liujunzi Decoction with sweet and bland Dampclearing Herbal Medicine with 32 subjects. The first group patients were treated by Potassium Magnesium Aspartate Tablets Panangin and Reduced Glutathione for Injection; The second group patients were treated by Chaishao Liujunzi Decoction; The third group patients were treated by Chaishao Liujunzi Decoction with sweet and bland Dampclearing Herbal Medicine. One course of treatment lasts one month. Before and after treatment; liver function (ALT, AST, ALB, TBIL) and index of liver fibrosis (CG, HA, PCⅢ), viral replication index (HBV-DNA) were detected respectively, making judgement for curative effect by grading scoring of contrasting clinical symptoms and physical sign.Results:1. Symptoms and syndrom scoring Symptoms and syndrom scoring of the patients in these three groups has dropped significantly (P<0.01) after the treatment. The second group has fallen more explicitly than the first group(P<0.05), while the third group has fallen more explicitly than the second group (P< 0.01)2. Liver function:The patients in these three groups after treatment can significantly improve patients'liver function index ALT, AST and TBIL (P<0.05 or P＜0.01), without influence on ALB. ALT, AST and TBIL in the second group and the third group have fallen significantly than that in the first group (P< 0.05 or P＜0.01),which has a statistic significance. The decreasing amplitude of ALT and AST in the third group is much greater, compared to that in the second group, which has a statistic significance (P<0.05或P＜0.01). However, the decreasing amplitude of TBIL has no statistic significance between the third and the second group.3. Index of liver fibrosis:Index of liver fibrosis (CG) of the patients in these three groups is significantly improved after treatment (P＜0.05 or P＜0.01). Compared to the first group, the third group has greatly raised in the index of liver fibrosis, which has a statistic significance between them (P＜0.05). However, as for-the Index of liver fibrosis, there is no statistic significance (P>0.05)between the third group and the second group. The findings of the three group's HA' s changes have the similar law as the results of CG's changes, except the first group, in which there is no statistic significance (P＞0.05). The changes and D-value of PCIII in these three groups have no statistic significance (P＞0.05) after treatment, compared to that before treatment.4. HBV-DNA quantitate:HBV-DNA quantitate of the patients has somewhat fallen in the first group after treatment, but there is no statistic significance (P＞0.05). Compared to that of the first group, HBV-DNA quantitate of the patients in the second and third group have obviously fallen after treatment, and the difference is significant (P＜0.05). As for the decreasing amplitude, there is no statistic significance (P＞0.05).5. curative effect:The effective rate of cure amounts to 51.61%,68.75% and 96.88% in the first, second and third group respectively. The curative effect in the second and third group has statistic significance (P<0.05 or P<0.01) after treatment.compared to the first group. The curative effect in the third group excels that in the second group (P<0.05)Conclusions:1. HBV has the features of damp evil. The hidden dampness of HBV is the internal factors resulted in lier constraint and insufficiency of the spleen of chronic HBV patients from occult syndromes, which carry hidden dampness.2. The most effective curative to get rid of lier constraint and insufficiency of the spleen of chronic HBV patients with hidden dampness is to use repeling dampness medicine of bland and sweet drugs to reinforce the spleen.3. Chaishao Liujunzi Decoction with Sweet and bland Dampclearing Herbal Medicine has good curative effect to treat lier constraint and insufficiency of the spleen of chronic HBV patients with hidden dampness.