| Background and Objective MRI play a prominent role in the diagnosis and differential diagnosis of breast disease, in particular diffusion-weighted imaging(DWI) and dynamic contrast enhanced(DCE-MRI). The purpose of this research is evaluate the diagnosis value of 3.0T magnetic resonance diffusion-weighted imaging and dynamic enhanced MRI between benign and malignant breast lesions and the diagnosis value of comparing the parameters .Methods A total of 47 patients were included in the study,in which 22 patients had benign breast lesions and 26 patients had lesions of breast carcinoma patients diagnosed pathologically. The tradition MR imaging,DWI and DCE-MRI were performed.the MRI findings were retrospectively analyzed.Then the mean values of apparent diffusion coefficient(ADC), maximum slope of increase(MSI), signal enhancement ratio(SER), maximum signal intensity(SImax) and the time to peak(Tpeak) of the lesions were determined separately.Compared with the normal tissues,then the the mean values of relative apparent diffusion coefficient(rADC),relative maximum slope of increase(rMSI), relative signal enhancement ratio(rSER), relative maximum signal intensity(rSIm) and SId of the lesions were determined separately,too. The differential diagnoistic value of these parameters were analyzed.The receiver operator characteristic curve(ROC) of the patients were used to definite the thresholds.Results The mean ADC values of benign and malignant breast lesions were (1.54±0.35) and (0.97±0.19)·10-3 mm2·sec-1,the mean values of rADC were (0.82±0.19) and (0.51±0.08)·10-3 mm2·sec-1,the mean values of MSI were (929.91±467.6) and (1487.47±336.25),the mean values of rMSI were (6.79±2.47) and (10.22±2.55),the mean values of SER were (42.24±28.69) and (100.52±20.09), the mean values of rSER were (3.17±2.19) and (5.95±3.17), the mean values of SImax were (2557.47±542.40) and(2472.65±346.21), the mean values of SId were (1890.23±489.70) and (1770.03±303.60),the mean values of Tpeak were (503.63±165.05) and (214.73±85.36). The mean values of ADC, rADC,MSI,rMSI,SER,rSER and Tp which were obtained in malignant breast lesions was significantly different from those obtained in benign lesions. The mean SIm and SId values were no significantly difference.The ROC of patients was made with the parameters all above used as diagnostic criteria. The areas of ADC, rADC, MSI, rMSI, SER, rSER, SIm, SId and Tp were 0.944, 0.974, 0.187, 0.123, 0.083, 0.202, 0.565, 0.589 and 0.900,approximately.And the ADC,rADC and Tp had better diagnosis values(>0.900). The diagnosis thresholds of ADC,rADC and Tp between benign and malignant breast lesions were 1.17×10-3,0.67,395,and the sensitivity and the specificity were (90.5%,91.7%),(95.2%,100.0%) and (86.4%,96.2%).Conclusions1. DWI and DCE-MRI both played important roles in the diagnosis of benign and malignant breast lesions.2. ADC,rADC and Tp had better diagnosis performances than any other parameters.3. MSI,rMSI,SER and rSER had certain values in the diagnosis of benign and malignant breast lesions,but the diagnostic performances were poor. Objective:Through the MR scan of DCE and DWI,analysis all of the parameters of MR which get from image postprocessing ,including:ADC,rADC,MSI,rMSI,SER,rSER,Tpeak,To reveal the relationship between the parameters and prognostic factors of tumor,including:Ki-67,HER-2,ER and PR,and explore the feasibility of prognosis of breast cancer in vivo。Methods A total of 20 women with breast cancer underwent breast DWI and DCE-MRI.the mean values of apparent diffusion coefficient(ADC), maximum slope of increase(MSI), signal enhancement ratio(SER),and the time to peak(Tpeak) of the lesions were determined separately.Compared with the normal tissues,then the the mean values of relative apparent diffusion coefficient(rADC),relative maximum slope of increase(rMSI) and relative signal enhancement ratio(rSER) of the lesions were computed separately,too. Histological records were reviewed for histologic grade, and expression of estrogen receptors (ER), progesterone receptors (PR), HER-2 and Ki-67。Correlations of DWI and DCE-MRI findings with prognostic factors were determined using the independent-sample T test and the Spearman's rank correlation test。Result There was a positive correlation of the MSI value with Ki-67 (P=0.042), a significant positive correlation of rMSI value with HER-2(P=0.008), a significant positive correlation of SER with Ki-67 and HER-2(P=0.008,P=0.041); There was a significant negative correlation of Tpeak and Ki-67(P=0.025)。rMSI value of Ki-67 negative express(9.33±1.58) is significantly lower than that (11.98±2.75) of Ki-67 positive express(P=0.048),rMSI value of HER-2 negative express(8.94±1.13)is significantly lower than that(10.90±2.52)of positive express(P=0.032);SER value of HER-2 negative expres(s84.11±21.70)is significantly lower than tha(t107.37±17.64) of positive express(P=0.021);otherwise,Tp value of HER-2 negative express(284.83±97.02) is significantly higher than tha(t185.07±63.10) of positive express(P=0.013)。There were no correlations between the ADC value and rADC value and prognostic factors,No such correlation has been found between other parameters and prognostic factors。Conclusions:1. There was a positive correlation of DCE-MRI parameters(rMSI and SER)with Ki-67and HER-2,a negative correlation of Tpeak with Ki-67 and HER-2,DCE-MRI could predict patient prognosis.2. There was no correlation between the ADC value and rADC value and prognostic factors.3. No such correlation has been found between ER and PR and DCE-MRI and DWI.
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