A Study Of Correlation Between The Anti-beta2 Glycoprotein â…  Antibodies And Acute Coronary Syndrome

Objective To investigate the correlation between the anti beta2 glycoproteinⅠantibodies (anti-β2GPI) and acute coronary syndrome(ACS).Methods The study comprised 168 acute coronary syndrome(ACS) patients in cardiovascular medicine department of Chinese-Japanese friendship hospital from February 2008 to February 2009.There were 98 male patients and 70 female patients,64.3±8.3 years old.And all of patients will be test the coronary angiography (CAG) for learning the coronary arterial severe degree,and all of patients were revascularizated to the coronary artery(including percutaneous coronary artery intervention(PCI) or coronary artery bypass graft(CABG)). Patients with clinical diagnosis were divided into three groups,including ST-segment elevation acute myocadial infarction(STEMI), nonST-segment elevation acute myocadial infarction(NSTEMI),midrange and height risk Unstable angina(UA).The anti-β2GPI antibodies tite level were detected using ELISA. All the patients were divided into three groups according to the resuts of the antibodies' tite,including high (≥100RU/ml),middle(20-100 RU/ml) and low(≤20RU/ml) tite level groups.To compare with the correlation between antibodies' tite level and the prognosis in ACS, All of patients were followed up for 12 months until the end event. Primary end event is the main adverse cardiac events(MACEs).Then using the statistical analysis coronary arterial disease severe degree and prognosis to evaluate the association of anti-β2GPI antibodies with ACS.Results All of ACS patients were maken the operation of PCI(161 patients) or CABG(7 patients). The anti-β2GPI tite level in the serum of patients diagnosed ST-segment elevation acute myocardial infarction nonST-segment elevation acute myocardial infarction and unstable angina were 63.4±32.6RU/ml,39.8±25.9 RU/ml,22.1±10.4 RU/ml respectively.From the results,the most highest one was STEMI s patients,the second was NSTEMI s patients,the third was UA s patients(all P<0.01).In the high tite level group of anti-β2GPI, STEMI was 90.9%(10/11),the comparison with middle(29/96) and low(1/61) groups was apparente(all P<0.01).All of patients were followed up for outcomes untill 12 months,and the follow-up rate was 98%.Patients who had high tite level of anti-β2GPI with MACEs were 4 instances,and the incidence rate of MACEs was 36.4%.It had more adverse events than patients who were middle(4.2%) and low tite level(3.3%)(all P<0.01). High tite level of anti-β2GPI was one of the independent risk factors in ACS because it had determinate predictive value to MACEs in ACS patients by logistic regeression analysis.Conclusion Anti-β2GPI was associated with the severity and adverse outcomes of conorary arterial disease. High tite level of anti-β2GPI was one of the independent risk factors in ACS because it had determinate predictive value to MACEs in ACS patients.