| Objective:To study the clinical features of cytomegalovirus (CMV) infection in neonates. Method:A retrospective analysis of the clinical manifestation, laboratory examination and target organ damages among 75 neonates who were diagnosed with CMV infection and hospitalized in the Affiliated Children's Hospital of Zhejiang University, School of Medicine from January 1st 2007 to January 1st 2011. Results: The main clinical manifestations of CMV infection in neonates were jaundice, petechia, convulsion and tachypnea. Productive infection was found in 52 cases, among which 22 were diagnosed with CMV diseases. The common complications were hepatitis (9 cases), thrombocytopenia (8 cases), abnormal brainstem auditory evoked potential (BAEP) (8 cases) and pneumonia (5 cases).27.3% of the preterm infants had hearing deficit.41 patients were diagnosed with congenital CMV infection, among which 11 were diagnosed with congenital heart disease. There were 22 serum CMV-IgM negative cases, but all of them had urine CMV-DNA copies positive, with 2 cases of hepatitis,2 cases of hearing screening failure and 9 cases of jaundice of unknown cause.17 patients received antiviral therapy with ganciclovir, but a descent of peripheral white blood cell count was observed in 3 cases after the antiviral therapy. Conclusion:CMV infection should be taken in consideration when the neonates present jaundice of unknown cause, hepatitis, thrombocytopenia and pneumonia that can't be explained by common pathogens in respiratory tract. Patients with CMV-IgM negative result should receive examinations of blood platelets level, urine CMV-DNA copy, liver function and BAEP, and be followed up to avoid missed diagnosis of possible CMV disease.
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