Correlation Between Coagulation Disorders And Sepsis Severity And Prognosis.

ObjectiveRetrospectively study the patients with sepsis admitted to the ICU and emergency department of Sir Run Run Shaw Hospital, statistics the probability of coagulation disorders, and discuss the relationship between coagulation disorders and sepsis severity and prognosis. To early detect and improve coagulation dysfunction, to prevent sepsis developing to MODS and to improve the survival of the hospitalized septic patients.MethodsSelect 134 patients meeting sepsis diagnostic criteria admitted to ICU and emergency department of Sir Run Run Shaw Hospital affiliated to Zhejiang University from 2010.6 to 2011.1 and we measured blood coagulation function incluing D-dimer,platelet count and so on, to complete the clinical screening of DIC on the same day admitted to hospital as well as the first 3,7 days after admission respectively. All the patients were divided into sepsis group and severe sepsis group according to the disease severity, divided into survival group and dead group according to outcomes, divided into DIC group and non-DIC group according to coagulation dysfunction or divided into low molecular heparin group and control group according to intervention.ResultsCompared to sepsis group, patients with severe sepsis had significant higher D-dimer levels and higher risk of mortality and DIC occurrence (P<0.05).However, no significance of the hospitalized days beteen two groups was found (P>0.05).Compared to survival group, patients in death group had significant higher D-dimer levels and higher risk of DIC occurrence (P<0.05). Plasma D-dimer were significantly higher in DIC-group and septic DIC group than that of non-DIC group (P<0.01). No significance of the mortality and efficacy was found between low molecular heparin group and control group(P> 0.05).ConclusionsPatients with sepsis was associated with significant coagulation disorders. D-dimer levels were significantly higher in severe sepsis group than sepsis group, were significantly higher in the survival group than dead group, and were significantly higher in DIC-group than non-DIC group. Coagulation disorders increased severity and aggravated prognosis. Early detection and improving coagulation disorders can reduced mortality in septic patients.