Analysis Of Clinical Related Factors Of Postoperative Epilepsy Of Gliomas In Earlier Period

Objective To explore the relationship between gliomas postoperative epilepsy and each clinical relating factor,analyze the main risk factor and protective factor,establish the logistic stepwise regression equation to make risk assessment of postoperative epilepsy of glioma.Methods Collecting the clinical data of 203 gliomas operative cases of our hospital between November 2002 and March 2011 and extract fifteen variables including gender,age,recurrence,preoperative epilepsy,language barrier,dyskinesia,tumor place,tumor direction,tumor diameter,peritumoral edema,preoperative or postoperative preventive drug,operative time,pathology and postoperative epilepsy from the clinical data.Taking gender,age,recurrence,preoperative epilepsy,language barrier,dyskinesia,tumor place,tumor direction,tumor diameter,peritumoral edema,preoperative or postoperative preventive drug,operative time,pathology as observed indexes to analyze the relationship between these 14 factors and gliomas postoperative epilepsy and establish the logistic stepwise regression equation to make risk assessment of postoperative epilepsy of gliomas using statistic software SPSS 13.0.Results1.In the 203 gliomas cases,there were 34 cases complicated with postoperative epilepsy.Its incidence was 16.7%.According to the contingency coefficient C,the sequence of clinical factors'dependability to postoperative epilepsy of gliomas was tumor recurrence(0.278),tumor place(0.268),postoperative preventive drug(0.230),pathology(0.202),preoperative preventive drug(0.200),preoperative epilepsy(0.200).2.The postoperative epilepsy incidence rates of the patients have preoperative epilepsy or not,the patients have preoperative preventive medication or not,the pathology,the patients have postoperative preventive medication or not,the patients have the gliomas in different places,the patient have tumor recurrence have significant difference(P<0.05).The other factor that gender,age,,language barrier,dyskinesia,tumor direction,tumor diameter,peritumoral edema,operative time statistics didn't correlate with postoperative epilepsy in statistics analysis(P>0.05).3.C value of preoperative epilepsy,preoperative preventive drug ,pathology,postoperative preventive drug,tumor place,tumor recurrence equal 0.200,0.200,0.202,0.230,0.268,0.278(P<0.05),the higher of the value,the closer of the correlation between variable and postoperative epilepsy stronger.4.Relative risk coefficient of preoperative epilepsy,tumor recurrence,low-grade gliomas exceed one,means these factors were risk factors,if these factors existence,the risk of postoperative epilepsy is high.Relative risk coefficient of preoperative preventivedrug,postoperative preventive drug less than one,means these factors were protection factors if these factors existence,the risk of postoperative epilepsy is low.5.From logistic regression analysis the relative risk coefficient of tumor place was 0.377.Among them and OR value the risk degree of tumor place was high .Their corresponding place is mainly convexity of brain,approaching domain .Conclusion1.The incidence of postoperative epilepsy is about 16.7%.2.The relationship of preoperative epilepsy,preoperative preventive drug ,pathology,postoperative preventive drug,tumor place and tumor recurrence to postoperative epilepsy is closer gradually(P<0.05).3.The incidence of postoperative epilepsy of patients who have preoperative epilepsy,tumor recurrence and low-grade gliomas is high.So they are risk factors.The incidence of postoperative epilepsy of patients who have preoperative opostoperative drug prevention is low.So they are protective factors.4.If the gliomas is in cortex,approaching cortex or approaching functional area,the incidence of postoperative epilepsy is high.If the gliomas is in deep part,the incidence of postoperative epilepsy is low.